Figure 2

Examples of how the different case report forms will be applied. Four different cases are summarized, encompassing treatment interruption or end in relation to the compilation of case report forms (CRFs). Case 1 is the easiest case. The patient is admitted to the intensive care unit (ICU), is treated with renal replacement therapy (RRT), ends treatment and is discharged. The patient has a single CRF. In case 2 the patient is admitted and is treated with RRT, but this treatment is stopped for longer than 18 hours (this is defined as treatment end). However, the patient is later started on RRT again. A new CRF (even if the modality is the same) will need to be completed. In this case, the patient has two or more CRFs (as in the case of more than one treatment stoppages for longer than 18 hours). In case 3 the patient is admitted and is started on RRT, which is stopped for less than 18 hours (defined as interruption). The patient is then restarted and the compilation is continued on the same CRF. Case 4 is similar to case 3, with the important difference being related to the change in modality following treatment interruption. In this case, each change of modality will require a new CRF.