Finding/study characteristic | Number of studies (%) | References |
---|---|---|
Decrease in RBF | 99 (62%) | 20, 21, 23, 24, 26-29, 37-45, 49-54, 58-64, 68-70, 73, 74, 76, 78, 80, 83-86, 88, 90-95, 98-101, 103-107, 109, 110, 112, 113, 118-121, 123, 124, 126, 128-131, 134, 135, 140, 143-145, 149, 150, 152-157, 159, 160, 163, 165, 168, 169, 171-175 and 178 |
No change or a decrease in RBF | 60 (38%) | 22, 25, 30-36, 46-48, 55-57, 65-67, 71, 72, 75, 77, 79, 81, 82, 87, 89, 96, 97, 102, 108, 111, 114-117, 122, 125, 127, 132, 133, 136-139, 141, 142, 146-148, 151, 158, 161, 162, 164, 166, 167, 170, 176 and 177 |
Conducted in small animals (rats, mice, rabbits and piglets) | 65 (41%) | 20, 24, 27, 28, 38, 40, 43-45, 49, 50, 59, 61, 62, 65-67, 71-74, 77, 78, 82, 87, 88, 90, 92, 93, 99, 100, 102-105, 109, 110, 112, 115, 116, 119-121, 126, 128, 133, 138, 139, 141, 145, 149, 150, 152, 155-157, 159, 160 and 164-170 |
Conducted in largane animals (dogs, pigs and sheep) | 94 (59%) | 21-23, 25, 26, 29-37, 39, 41, 42, 46-48, 51-58, 60, 63, 64, 68-70, 75, 76, 79-81, 83-86, 89, 91, 94-98, 101, 106-108, 111, 113, 114, 117, 118, 122-125, 127, 129-132, 134-137, 140, 142-144, 146-148, 151, 153, 154, 158, 161-163 and 171-178 |
Measurement of RBF using flow probes | 80 (50%) | 21, 23-26, 28, 29, 32, 33, 36, 42, 43, 46, 53-58, 60, 63, 65, 66, 68-70, 75, 79, 81-85, 89, 91, 92, 95, 98, 101, 104-108, 110, 111, 113, 115, 116, 118, 122, 124-127, 129, 131, 132, 134-136, 142-144, 148, 153, 158-163 and 171-178 |
Measurement of RBF using other methods | 79 (50%) | 20, 22, 27, 30, 31, 34, 35, 37-41, 44, 45, 47-52, 59, 61, 62, 64, 67, 71-74, 76-78, 80, 86-88, 90, 93, 94, 96, 97, 99, 100, 102, 103, 109, 112, 114, 117, 119-121, 123, 128, 130, 133, 137-141, 145-147, 149-152, 154-157 and 164-170 |
Conducted in unconscious animals | 127 (80%) | 21-29, 37-44, 46, 53, 54, 57, 60-63, 65-75, 77-89, 91-101, 103-107, 109-111, 113, 115, 116, 118-121, 123-136, 138-160, 163, 164 and 166-178 |
Conducted in conscious animals | 32 (20%) | 20, 30-36, 45, 47-52, 55, 56, 58, 59, 64, 76, 90, 102, 108, 112, 114, 117, 122, 137, 161, 162 and 165 |
Conducted following a recovery period (after surgical preparation) | 33 (21%) | 30-36, 47-52, 55-59, 64, 68, 70, 76, 102, 108, 112, 114, 117, 122, 137, 161, 162, 166 and 170 |
Conducted with no recovery period | 126 (79%) | 20-29, 37-46, 53, 54, 60-63, 65-67, 69, 71-75, 77-101, 103-107, 109-111, 113, 115, 116, 118-121, 123-136, 138-160, 163-165, 167-169 and 171-178 |
Short period of observation following induction of sepsis (<2 hours) | 47 (29%) | 22, 26, 27, 40, 41, 47, 49, 50, 57, 59-61, 67, 70, 79, 80, 82, 86, 89, 92, 99, 100, 103, 105, 106, 109, 111, 117, 120, 121, 123, 124, 129, 130, 145-147, 149-151, 153, 154, 156, 158, 163, 164 and 167 |
Long period of observation following induction of sepsis (>2 hours) | 112 (71%) | 20, 21, 23-25, 28-39, 42-46, 48, 51-56, 58, 62-66, 68, 69, 71-78, 81, 83-85, 87, 88, 90, 91, 93-98, 101, 102, 104, 107, 108, 110, 112-116, 118, 119, 122, 125-128, 131-144, 148, 152, 155, 157, 159-162, 165, 166 and 168-178 |
Use of LPS to induce sepsis | 100 (63%) | 21, 23-26, 28, 29, 37, 39, 40, 42-46, 50, 54, 58-61, 63, 65, 66, 68-72, 76, 79, 80, 82, 86-97, 101, 103-106, 109-111, 114-118, 120-127, 129-136, 141-144, 147-150, 153-158, 160-164, 171, 172 and 174-178 |
Use of injection of live bacteria or caecal ligation–perforation to induce sepsis | 59 (37%) | 20, 22, 27, 30-36, 38, 41, 47-49, 51-53, 55-57, 62, 64, 67, 73-75, 77, 78, 81, 83-85, 98-100, 102, 107, 108, 112, 113, 119, 128, 137-140, 145, 146, 151, 152, 159, 165-170 and 173 |
Fluid administered during the experimenta | 20 (13%) | 22, 27, 61, 68, 69, 72, 77, 78, 83, 85, 91, 113, 118, 121, 130, 135, 136, 144, 145 and 150 |
Fluid not administered during the experimenta | 106 (67%) | 21, 23-26, 28-32, 34-41, 43-46, 48-52, 54-59, 62-66, 71, 73-76, 79, 80, 82, 84, 87, 90, 92-101, 103-105, 107, 108, 111, 112, 114-116, 119, 122-129, 131, 137-140, 143, 146-148, 151-153, 155, 157-159, 161, 162, 165-167, 169, 170, 173-176 and 178 |
Conducted in hypodynamic sepsisb | 42 (26%) | 37, 39, 42-44, 53, 54, 58, 61, 63, 68, 69, 80, 84, 86, 89, 98, 101, 103, 107, 113, 118, 120, 121, 127, 129, 132, 140, 144, 149, 151, 154-157, 165, 172-174 and 178 |
Conducted in hyperdynamic sepsisb | 42 (26%) | 20, 26, 30-36, 41, 46-48, 51, 55-57, 76-79, 81, 83, 96, 97, 100, 102, 105, 111, 117, 122, 123, 125, 131, 150, 153, 158, 161, 162 and 175-177 |
Decreased COc | 51 (32%) | 21, 25, 29, 37-39, 42-44, 53, 54, 58, 59, 61, 63, 68, 69, 80, 84, 86, 88, 89, 98, 101, 103, 107, 112, 113, 118, 120, 121, 127-130, 132, 140, 144, 149, 151, 154-157, 165, 168, 169, 172-174 and 178 |
Unchanged or decreased COc | 67 (42%) | 20, 26, 27, 30-36, 40, 41, 46-52, 55-57, 64, 73, 74, 76-79, 81, 83, 90, 96, 97, 99, 100, 102, 105, 108, 111, 114, 117, 119, 122, 123, 125, 131, 133, 137-139, 141, 145, 148, 150, 152, 153, 158, 161, 162, 164, 166, 167, 170 and 175-177] |