Variable | Isolation of Aspergillus spp. | Candida spp. infection | Noncolonized, uninfected patients | P |
---|---|---|---|---|
Patients (n) | 36 | 105 | 720 | |
Age (years; mean ± SD) | 58.7 ± 16.6) | 59.5 ± 16.3 | 56.4 ± 17.4 | NS |
Men (n [%]) | 27 (75) | 76 (72.4) | 491 (68.2) | NS |
APACHE II score (mean ± SD) | 21.6 ± 6.9 | 18.5 ± 6.5 | 18.9 ± 8.1 | 0.05 |
ICU stay (days; mean ± SD) | 32.1 ± 21.4) | 32.8 (22.6) | 18.4 (14.1) | <0.001 |
Risk factors before ICU admission (n [%]) | ||||
Diabetes mellitus | 5 (13.9) | 18 (17.1) | 113 (15.7) | NS |
COPD | 16 (44.4) | 16 (15.2) | 179 (24.9) | 0.002 |
Solid neoplasm | 3 (8.3) | 21 (20) | 65 (9) | 0.002 |
Hematological neoplasm | 1 (2.8) | 3 (2.9) | 18 (2.5) | NS |
Transplant recipient | 3 (8.3) | 0 | 3 (0.4) | <0.001 |
Immunosuppression | 10 (27.8) | 8 (7.6) | 48 (6.7) | <0.001 |
Chronic renal failure | 3 (8.3) | 4 (3.8) | 26 (3.6) | NS |
HIV infection | 1 (2.8) | 2 (1.9) | 9 (1.3) | NS |
Chronic liver disease | 2 (5.6) | 3 (2.9) | 29 (4) | NS |
Severe heart failure | 2 (5.6) | 4 (3.8) | 41 (5.7) | NS |
Radiation therapy | 0 | 4 (3.8) | 7 (1) | NS |
Chemotherapy | 2 (5.6) | 3 (2.9) | 13 (1.8) | NS |
Risk factors during ICU stay | ||||
Arterial catheter | 31 (86.1) | 74 (70.4) | 498 (69.1) | NS |
Venous catheter | 36 (100) | 104 (99.0) | 711 (98.6) | NS |
Urinary catheter | 36 (100) | 100 (95.2) | 703 (97.5) | NS |
Mechanical ventilation | 35 (97.2) | 99 (94.2) | 640 (88.8) | 0.019 |
Total parenteral nutrition | 20 (55.5) | 90 (85.7) | 274 (38.0) | <0.001 |
Haemodialysis | 11 (30.6) | 34 (32.3) | 56 (7.8) | <0.001 |
Neutropenia | 5 (13.8) | 5 (4.7) | 20 (2.8) | 0.001 |
Steroids | 25 (69.4) | 25 (23.8) | 139 (19.3) | <0.001 |
Antibiotic treatment | 36 (100) | 105 (100) | 674 (93.5) | <0.001 |