|
Variable
|
Isolation of Aspergillus spp.
|
Candida spp. infection
|
Noncolonized, uninfected patients
|
P
|
|---|
|
Patients (n)
|
36
|
105
|
720
| |
|
Age (years; mean ± SD)
|
58.7 ± 16.6)
|
59.5 ± 16.3
|
56.4 ± 17.4
|
NS
|
|
Men (n [%])
|
27 (75)
|
76 (72.4)
|
491 (68.2)
|
NS
|
|
APACHE II score (mean ± SD)
|
21.6 ± 6.9
|
18.5 ± 6.5
|
18.9 ± 8.1
|
0.05
|
|
ICU stay (days; mean ± SD)
|
32.1 ± 21.4)
|
32.8 (22.6)
|
18.4 (14.1)
|
<0.001
|
|
Risk factors before ICU admission (n [%])
|
|
Diabetes mellitus
|
5 (13.9)
|
18 (17.1)
|
113 (15.7)
|
NS
|
|
COPD
|
16 (44.4)
|
16 (15.2)
|
179 (24.9)
|
0.002
|
|
Solid neoplasm
|
3 (8.3)
|
21 (20)
|
65 (9)
|
0.002
|
|
Hematological neoplasm
|
1 (2.8)
|
3 (2.9)
|
18 (2.5)
|
NS
|
|
Transplant recipient
|
3 (8.3)
|
0
|
3 (0.4)
|
<0.001
|
|
Immunosuppression
|
10 (27.8)
|
8 (7.6)
|
48 (6.7)
|
<0.001
|
|
Chronic renal failure
|
3 (8.3)
|
4 (3.8)
|
26 (3.6)
|
NS
|
|
HIV infection
|
1 (2.8)
|
2 (1.9)
|
9 (1.3)
|
NS
|
|
Chronic liver disease
|
2 (5.6)
|
3 (2.9)
|
29 (4)
|
NS
|
|
Severe heart failure
|
2 (5.6)
|
4 (3.8)
|
41 (5.7)
|
NS
|
|
Radiation therapy
|
0
|
4 (3.8)
|
7 (1)
|
NS
|
|
Chemotherapy
|
2 (5.6)
|
3 (2.9)
|
13 (1.8)
|
NS
|
|
Risk factors during ICU stay
|
|
Arterial catheter
|
31 (86.1)
|
74 (70.4)
|
498 (69.1)
|
NS
|
|
Venous catheter
|
36 (100)
|
104 (99.0)
|
711 (98.6)
|
NS
|
|
Urinary catheter
|
36 (100)
|
100 (95.2)
|
703 (97.5)
|
NS
|
|
Mechanical ventilation
|
35 (97.2)
|
99 (94.2)
|
640 (88.8)
|
0.019
|
|
Total parenteral nutrition
|
20 (55.5)
|
90 (85.7)
|
274 (38.0)
|
<0.001
|
|
Haemodialysis
|
11 (30.6)
|
34 (32.3)
|
56 (7.8)
|
<0.001
|
|
Neutropenia
|
5 (13.8)
|
5 (4.7)
|
20 (2.8)
|
0.001
|
|
Steroids
|
25 (69.4)
|
25 (23.8)
|
139 (19.3)
|
<0.001
|
|
Antibiotic treatment
|
36 (100)
|
105 (100)
|
674 (93.5)
|
<0.001
|
- APACHE, Acute Physiology and Chronic Health Evaluation; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; NS, not significant; SD, standard deviation.
