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Table 1 Clinically appropriate methods to quantify pulmonary edema

From: The measurement of lung water

 

Measures

Quantitation

Accuracy*

Reproducibility (COV)

Sensitivity†

CXR

LD

Poor

Unknown

Unknown

Moderate

CT

LD

Excellent

Unknown‡

Unknown‡

High

NMR

TLW

Fair

Underestimates by -40%§

5-10%

Poor¶

PET

EVLW

Excellent

Underestimates by 10-15%

< 5%

High

ID

EVLW

Good-excellent

Overestimates by 10-20%#

4-8%

Moderate

  1. *None of the methods can distinguish whether anincrease in extravascular lung water (EVLW) represents non-cellular pulmonaryedema or cellular water from an inflammatory infiltrate.†Sensitivity to change. ‡Presumablyexcellent, but formal studies never performed. §Theunderestimates are primarily in normal or mildly edematous lungs.¶The poor sensitivity is primarily in normal or mildlyedematous lungs. #The overestimation is primarily in normal ormildly edematous lungs. TLW, total lung water (of a region on an image); LD,lung density; COV, coefficient of variation; CXR, chest X-ray; CT, computedtomography; NMR, nuclear magnetic resonance; PET, positron emission tomography;ID, indicator dilution methods.