Baseline characteristics and outcomes | Canadian ENHANCE (n = 305) | Global ENHANCE (n = 2378) |
---|---|---|
Mean age, years (SD) | 56.9 (17.2) | 59.1 (16.9) |
APACHE II ICU (SD) | 25.3 (7.8) | 22.0 (7.4) |
# Organ failure (SD) | 3.1 (1.2) | 2.7 (1.1) |
Baseline SOFA (SD) | 10.9 (3.6) | 9.7 (3.5) |
Vasopressor use (%) | 82% | 74% |
Mechanical ventilation (%) | 90% | 82% |
Infusion serious bleed (%) | 2.0% | 3.6% |
28-Day serious bleed (%) | 3.9% | 6.5% |
Infusion ICH (%) | 0.3% | 0.6% |
28-Day mortality (%) | 22.6% | 25.3% |