Nerve growth factor levels rise following cardiopulmonary bypass in children: a novel mediator in the systemic inflammatory response syndrome?

Table

	Pre-op	End-CPB	1 h post-CPB	2 h post-CPB	24 h post-CPB
NGF (pg/ml)	199.5	1023.3	3198.9	3382.2	1398.6
Cl	(64.7-615.2)	(429.6-2437.2)	(1692.8-6045.0)	(1838.6-6221.6)	(504.5-3827.4)
P value		≤ 0.05	≤ 0.05	≤ 0.05	≤ 0.05
IL-6 (pg/ml)	4.1	40.4	167.5	252.4	66.1
Cl	(1.4-12.2)	(17.0-96.3)	(101.6-276.0)	(152.1-418.8)	(39.9-109.6)
P value		≤ 0.05	≤ 0.05	≤ 0.05	≤ 0.05
IL-8 (pg/ml)	5.5	36.0	111.1	97.2	20.3
Cl	(2.0-15.2)	(20.6-62.7)	(74.9-165.0)	(57.0-165.6)	(8.1-50.9)
P value		≤ 0.05	≤ 0.05	≤ 0.05	≤ 0.05

Data are expressed as geometric means of log-transformed values with 95% confidence interval (CI). Single factor analysis of variance (ANOVA) and Student t test were used, as appropriate, to determine differences in NGF and cytokine levels at different time points. A P value ≤ 0.05 was accepted as significant.

ISSN: 1364-8535