Table 1
From: Effects of sarpogrelate, a 5-hydroxytriptamine 2A receptor antagonist on endotoxin shock in rats
| Â | 0 mg/kg | 3 mg/kg | 10 mg/kg |
|---|---|---|---|
Blood pressure (mmHg) | 45 ± 26 | 90 ± 18* | 80 ± 21* |
Pulse rate (beats/min) | 105 ± 35 | 285 ± 25* | 278 ± 29* |
Survival rate | 3/20 | 18/20* | 15/20* |
IL-1β (pg/ml) | 244 ± 56 | 85 ± 33* | 53 ± 15* |
IL-6 (ng/ml) | 6.8 ± 1.7 | 5.4 ± 1.8 | 7.1 ± 2.9 |
IL-8 (ng/ml) | 46.0 ± 16.7 | 35.4 ± 9.7 | 38.4 ± 10.1 |
IL-10 (pg/ml) | 844 ± 384 | 1047 ± 520 | 1163 ± 315 |
Tumor necrosis factor α (ng/ml) | 2.2 ± 0.5 | 2.0 ± 0.9 | 2.1 ± 0.6 |