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Figure 1 | Critical Care

Figure 1

From: Microvascular permeability during experimental human endotoxemia: an open intervention study

Figure 1

Changes in inflammatory parameters. Administration of endotoxin (n = 8; 2 ng/kg) resulted in a marked increase in tumour necrosis factor (TNF)-α (closed squares, left axis) and IL-1β (open squares, right axis). In control individuals cytokine levels remained below the detection limit (n = 8; data not shown). Cytokine release was associated with fever and an increase in C-reactive protein (CRP; endotoxin group, closed squares; control group, open circles). Data are expressed as means ± standard error of the mean. The P values in the figure refer to the difference between endotoxin and control groups as analyzed using analysis of variance with repeated measures over the complete curve.

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