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Table 1 Baseline demographic characteristics and outcomes for all patients with severe sepsis

From: Extravascular lung water in patients with severe sepsis: a prospective cohort study

 

ARDS

Non-ARDS

Total

Patients (n)

15

14

29

Baseline characteristics

   Age (years)

44 ± 12

57 ± 14

51 ± 15*

   Sex (male)

5/15

5/14

10/29

   Race (African American/Caucasian/other)

12/3/0

12/0/2

24/3/2

   Chronic heart disease

1/15

2/14

3/29

   Chronic obstructive lung disease

1/15

1/15

2/29

   Chronic renal disease (serum creatinine ≥ 2.0 mg/dl)

1/15

3/14

4/29

   HIV infection

7/15

4/14

11/29

   Chronic alcohol abuse

5/15

8/14

13/29

   Bacteremia

7/15

5/14

12/29

   APACHE II score (day 1)

23.9 ± 6.5

27.7 ± 8.3

25.7 ± 7.5

   Mechanically ventilated

14/15

11/14

25/29

Physiology at enrollment

   White blood cell count (cells × 103/ml)

20.4 (10.8–30.0)

13.6 (3.8–23.4)

17.2 (8.9–25.5)

   Prior 24-hour fluid balance (ml)

2506 ± 2583

4993 ± 3625

3523 ± 3223

   Shock (vasopressor requirement)

12/15

10/14

22/29

   Cardiac index (l/min per m2)

3.8 ± 1.0

4.3 ± 1.4

4.0 ± 1.2

   GEDV index (ml/m2)

648 ± 184

719 ± 119

681 ± 159

   SVRI (dyn·s/cm5 per m2)

1408 ± 441

1668 ± 669

1528 ± 562

   EVLW index (ml/kg)

15.0 (9.0–16.7)

7.0 (5.0–8.2)

8.5 (5.1–15.8)*

Outcome

   ICU length of stay (days)

14.0 (8.5–21.0)

10.0 (4.8–16.3)

13.0 (7.0–17.0)

   Hospital length of stay (days)

26.0 (12.3–42.3)

19.0 (16.0–31.0)

19.0 (13.0–36.0)

   28-day mortality

7/15

5/14

12/29

  1. Values are expressed as mean ± standard deviation, frequency (%), or median (interquartile range), unless otherwise noted.
  2. * P for difference between groups < 0.05. APACHE, Acute Physiology and Chronic Health Evaluation; ARDS, acute respiratory distress syndrome; EVLW, extravascular lung water; GEDV, global end-diastolic volume; ICU, intensive care unit; SVRI, systemic vascular resistance index.