Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery – a systematic literature review

Gillies, Michael; Bellomo, Rinaldo; Doolan, Laurie; Buxton, Brian

doi:10.1186/cc3024

Critical Care

Table 2 Summary of literature search results for dobutamine

From: Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery – a systematic literature review

Ref.	n	Year	Study design	Level of evidence	Comparator	Dose (μg/kg per min)	End-points
[2]^a,b	120	2001	Multicentre, prospective, unblinded, randomized trial	II	Milrinone	10–20	Haemodynamic parameters
[26]	10	2000	Prospective, blinded, randomized, crossover study	III	Dopamine, dopexamine	2.7	Jejunal perfusion
[30]^a	64	2000	Prospective, blinded, randomized, controlled trial	II	Placebo, ranitidine	4.0	pHi
[31]^a	17	1999	Prospective, blinded, randomized, controlled trial	II	Placebo	6.0	Haemodynamic parameters, splanchnic blood flow
[32]^a	110	1999	Observational study	III	-	0–40	Haemodynamic parameters
[14]	30	1997	Prospective, blinded, randomized trial	II	Enoximone, epinephrine	3.0	IMA graft flow
[33]^a,c	20	1997	Prospective, unblinded, randomized trial	II	Enoximone	8.0	Haemodynamic parameters
[34]^c	20	1997	Prospective, blinded, randomized trial	II	Enoximone	5.0	Haemodynamic parameters
[35]^a,b	30	1996	Prospective, blinded, randomized trial	II	Enoximone	10.0	Haemodynamic parameters
[36]^a,b	28	1995	Prospective, unblinded, randomized controlled trial	II	Control	4.4	Haemodynamic parameters, pHi, ICG Clearance
[37]^a,b	10	1994	Prospective, blinded, randomized trial	II	Dopexamine	5.0–10.0	Haemodynamic parameters
[18]^c	75	1993	Prospective, blinded, randomized trial	II	Enoximone, dopamine	5.0	Haemodynamic parameters
[38]^a,b	16	1993	Prospective, unblinded, nonrandomized controlled trial	III	Sodium nitroprusside, control		Haemodynamic parameters ICG Clearance
[10]	52	1992	Observational study	III	Epinephrine	2.5–5.0	Haemodynamic parameters
[39]^a,b	30	1992	Prospective, unblinded, randomized trial	II	Amrinone	5–15	Haemodynamic parameters
[40]	10	1992	Observational study	III	Various dose ratios of dopamine/dobutamine	0–10.0	Haemodynamic parameters
[41]^a	20	1990	Prospective, unblinded, randomized trial	II	Enoximone	5.0	Haemodynamic parameters
[42]^a	20	1990	Prospective, unblinded, randomized trial	II	Enoximone	10.0	Haemodynamic parameters
[43]^a,b	40	1990	Prospective, unblinded, randomized trial	II	Enoximone	5–7	Haemodynamic parameters
[44]^a	50	1990	Prospective, unblinded, randomized trial	II	Enoximone	5.0	Haemodynamic parameters
[11]^a	16	1986	Prospective, unblinded, randomized, trial	II	Epinephrine	4.8	Haemodynamic parameters
[45]^a,b	9	1986	Sequential, cross-over study	III	Dopamine	5–10.0	Haemodynamic parameters
[16]	20	1982	Prospective, blinded, randomized trial	II	Dopamine	2.5–10.0	Haemodynamic parameters

^aPostoperative support. ^bCardiac index <2.5 l/min per m² or preoperative left ventricular ejection fraction <0.4. ^cWeaning from cardiopulmonary bypass. ICG, indocyanine green; IMA, internal mammary artery; pHi, intramucosal pH.

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com