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Table 2 Summary of literature search results for dobutamine

From: Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery – a systematic literature review

Ref. n Year Study design Level of evidence Comparator Dose (μg/kg per min) End-points
[2]a,b 120 2001 Multicentre, prospective, unblinded, randomized trial II Milrinone 10–20 Haemodynamic parameters
[26] 10 2000 Prospective, blinded, randomized, crossover study III Dopamine, dopexamine 2.7 Jejunal perfusion
[30]a 64 2000 Prospective, blinded, randomized, controlled trial II Placebo, ranitidine 4.0 pHi
[31]a 17 1999 Prospective, blinded, randomized, controlled trial II Placebo 6.0 Haemodynamic parameters, splanchnic blood flow
[32]a 110 1999 Observational study III - 0–40 Haemodynamic parameters
[14] 30 1997 Prospective, blinded, randomized trial II Enoximone, epinephrine 3.0 IMA graft flow
[33]a,c 20 1997 Prospective, unblinded, randomized trial II Enoximone 8.0 Haemodynamic parameters
[34]c 20 1997 Prospective, blinded, randomized trial II Enoximone 5.0 Haemodynamic parameters
[35]a,b 30 1996 Prospective, blinded, randomized trial II Enoximone 10.0 Haemodynamic parameters
[36]a,b 28 1995 Prospective, unblinded, randomized controlled trial II Control 4.4 Haemodynamic parameters, pHi, ICG Clearance
[37]a,b 10 1994 Prospective, blinded, randomized trial II Dopexamine 5.0–10.0 Haemodynamic parameters
[18]c 75 1993 Prospective, blinded, randomized trial II Enoximone, dopamine 5.0 Haemodynamic parameters
[38]a,b 16 1993 Prospective, unblinded, nonrandomized controlled trial III Sodium nitroprusside, control   Haemodynamic parameters ICG Clearance
[10] 52 1992 Observational study III Epinephrine 2.5–5.0 Haemodynamic parameters
[39]a,b 30 1992 Prospective, unblinded, randomized trial II Amrinone 5–15 Haemodynamic parameters
[40] 10 1992 Observational study III Various dose ratios of dopamine/dobutamine 0–10.0 Haemodynamic parameters
[41]a 20 1990 Prospective, unblinded, randomized trial II Enoximone 5.0 Haemodynamic parameters
[42]a 20 1990 Prospective, unblinded, randomized trial II Enoximone 10.0 Haemodynamic parameters
[43]a,b 40 1990 Prospective, unblinded, randomized trial II Enoximone 5–7 Haemodynamic parameters
[44]a 50 1990 Prospective, unblinded, randomized trial II Enoximone 5.0 Haemodynamic parameters
[11]a 16 1986 Prospective, unblinded, randomized, trial II Epinephrine 4.8 Haemodynamic parameters
[45]a,b 9 1986 Sequential, cross-over study III Dopamine 5–10.0 Haemodynamic parameters
[16] 20 1982 Prospective, blinded, randomized trial II Dopamine 2.5–10.0 Haemodynamic parameters
  1. aPostoperative support. bCardiac index <2.5 l/min per m2 or preoperative left ventricular ejection fraction <0.4. cWeaning from cardiopulmonary bypass. ICG, indocyanine green; IMA, internal mammary artery; pHi, intramucosal pH.