Skip to main content

Table 2 Assessment of blood–brain barrier permeability by Evans blue dye content in brain tissue

From: Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study

Measurement

Group (n)

Left hemisphere

Right hemisphere

P

EB dye (μg/g)

C (8)

0.00160 ± 0.0003

0.00145 ± 0.0003

0.33

 

S (8)

0.00466 ± 0.0002a,b

0.00641 ± 0.0003c,d

0.13

 

C-Mg (8)

0.00135 ± 0.0002

0.00145 ± 0.0003

0.44

 

S-Mg (8)

0.00218 ± 0.0005

0.00199 ± 0.0007

0.57

KW

 

19.720

23.039

 

d.f.

 

3

3

 

P

 

< 0.001

< 0.0001

 
  1. Abbreviations: d.f., degrees of freedom; EB, Evans blue; KW, Kruskal–Wallis test statistic; P, approximate χ2 P value. Groups: sham control (C), sham control MgSO4-treated (C-Mg), septic (S) and septic MgSO4-treated (S-Mg). Data are expressed as means ± standard deviation.
  2. Dunn's multiple comparisons test: aseptic versus sham control, P < 0.01; bseptic versus sham control MgSO4-treated, P < 0.001; cseptic versus sham control, P < 0.001; dseptic versus sham control MgSO4-treated, P < 0.001. A Mann–Whitney test was used for within-group comparisons. Two-tailed P values are shown in the last column.