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Table 2 Assessment of blood–brain barrier permeability by Evans blue dye content in brain tissue

From: Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study

Measurement Group (n) Left hemisphere Right hemisphere P
EB dye (μg/g) C (8) 0.00160 ± 0.0003 0.00145 ± 0.0003 0.33
  S (8) 0.00466 ± 0.0002a,b 0.00641 ± 0.0003c,d 0.13
  C-Mg (8) 0.00135 ± 0.0002 0.00145 ± 0.0003 0.44
  S-Mg (8) 0.00218 ± 0.0005 0.00199 ± 0.0007 0.57
KW   19.720 23.039  
d.f.   3 3  
P   < 0.001 < 0.0001  
  1. Abbreviations: d.f., degrees of freedom; EB, Evans blue; KW, Kruskal–Wallis test statistic; P, approximate χ2 P value. Groups: sham control (C), sham control MgSO4-treated (C-Mg), septic (S) and septic MgSO4-treated (S-Mg). Data are expressed as means ± standard deviation.
  2. Dunn's multiple comparisons test: aseptic versus sham control, P < 0.01; bseptic versus sham control MgSO4-treated, P < 0.001; cseptic versus sham control, P < 0.001; dseptic versus sham control MgSO4-treated, P < 0.001. A Mann–Whitney test was used for within-group comparisons. Two-tailed P values are shown in the last column.