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Table 1 Comparison of cardiorespiratory variables before and after induction of lung injury

From: Cardiovascular stability during arteriovenous extracorporeal therapy: a randomized controlled study in lambs with acute lung injury

  CMV (n = 8) AV-ECMO (n = 9)
Variables Pre-injury Post-injury Pre-injury Post-injury
Minute volume (ml/kg/min) 408 ± 79 640 ± 144* 382 ± 109 561 ± 187*
PaO2 (mmHg) 389 ± 128 113 ± 85*** 393 ± 131 179 ± 86***
PaCO2 (mmHg) 37.1 ± 5.1 40.9 ± 3.1 36.7 ± 1.9 35.1 ± 3
Arterial pH 7.311 ± 0.05 7.263 ± 0.04 7.349 ± 0.05 7.344 ± 0.03††
HCO3- (mmol/l) 17.7 ± 3.2 17.4 ± 1.7 19.5 ± 2.8 18.3 ± 2.1
Arterial Hb-O2 (%) 99.8 ± 0.3 89.6 ± 11 99.8 ± 0.3 95.1 ± 11
O2-extraction (%) 28.0 ± 5.7 35.9 ± 4.9* 24.7 ± 8.1 35.7 ± 9.3*
Hb (g/dl) 9.4 ± 1.5 10.3 ± 2.0 8.1 ± 2.0 8.7 ± 2.3
MAP (mmHg) 84.2 ± 12.1 88.0 ± 10.9 96.7 ± 9.0 92.0 ± 14
PAP (mmHg) 13.1 ± 4.1 20.1 ± 5.7 14.5 ± 5.4 21.5 ± 4.9*
CO (ml/kg per min) 185 ± 23 164 ± 53 181 ± 69 173 ± 56
VO2 (ml/kg per min) 5.7 ± 2.2 8.7 ± 2.7* 5.4 ± 1.5 7.8 ± 2.5*
Body weight (kg)     
   All lambs 6.3 ± 1.7 - 8.5 ± 2.8 -
   Surviving lambs - 6.5 ± 1.3 - 11.0 ± 2.2
   Range 3.6–9.2 - 5.0–12.7 -
  1. Comparison of cardiorespiratory variables before and after induction of lung injury in surviving and nonsurviving lambs subjected to conventional mechanical ventilation (CMV) or arteriovenous (AV)-extracorporeal membrane oxygenation (ECMO) therapy. Values are expressed as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, pre-injury baseline versus post-injury baseline in the same group. P < 0.05, ††P < 0.01, pre-injury or post-injury baselines: CMV versus AV-ECMO. CO, cardiac output; Hb-O2, hemoglobin–oxygen saturation; MAP, mean arterial pressure; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; PAP, pulmonary artery pressure; VO2, oxygen consumption.