Comparisons between the minute ventilations (calculated per kg body weight) required to maintain normocapnia in lung-injured lambs subjected to conventional mechanical ventilation (CMV) or arteriovenous (AV)-extracorporeal membrane oxygenation (ECMO) with shunt flow of 15% of baseline cardiac output. Analysis of variance (ANOVA) followed by Dunnett multiple comparisons test was used to compare the preinjury level of minute ventilation in each group with subsequent measurements. ANOVA followed by Bonferroni test was used to compare CMV and AV-ECMO therapies at different time periods during the study period. Values are expressed as mean ± standard deviation. *P < 0.05. ALI, acute lung injury.