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Table 1 Comparison of options for stress ulcer prophylaxis

From: Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness

Characteristic Sucralfate Antacids H2RAs Esomeprazole Lansoprazole Omeprazole Pantoprazole Rabeprazole
Efficacy in elevating gastric pH   + + +++ +++ +++ +++ +++
Tolerability + + + +++ +++ +++ +++ +++
Use in organ failure        +  
Low potential for drug interactions        +  
Administration options         
   Oral     + + + + +
   Intravenous    + +   + +  
   Nasogastric + +   + + +   
  1. H2RAs, histamine H2 receptor antagonists.