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Table 1 Comparison of options for stress ulcer prophylaxis

From: Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness

Characteristic

Sucralfate

Antacids

H2RAs

Esomeprazole

Lansoprazole

Omeprazole

Pantoprazole

Rabeprazole

Efficacy in elevating gastric pH

 

+

+

+++

+++

+++

+++

+++

Tolerability

+

+

+

+++

+++

+++

+++

+++

Use in organ failure

      

+

 

Low potential for drug interactions

      

+

 

Administration options

        

   Oral

   

+

+

+

+

+

   Intravenous

  

+

+

 

+

+

 

   Nasogastric

+

+

 

+

+

+

  
  1. H2RAs, histamine H2 receptor antagonists.