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Table 3 Mechanisms of cellular destruction in rhabdomyolysis

From: Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians

Method Mechanism
Direct injury to cell membrane Crushing, tearing, burning, pounding, poisoning, dissolving
Muscle cell hypoxia leading to depletion of ATP Anerobic conditions: shock states, vascular occlusion, and tissue compression
Electrolyte disturbance disrupting the sodium–potassium pump Hypokalemia: vomiting, diarrhea, extensive diuresis
  Hyponatremia: water intoxication