Table 3 Mechanisms of cellular destruction in rhabdomyolysis
From: Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians
Method | Mechanism |
|---|---|
Direct injury to cell membrane | Crushing, tearing, burning, pounding, poisoning, dissolving |
Muscle cell hypoxia leading to depletion of ATP | Anerobic conditions: shock states, vascular occlusion, and tissue compression |
Electrolyte disturbance disrupting the sodium–potassium pump | Hypokalemia: vomiting, diarrhea, extensive diuresis |
Hyponatremia: water intoxication |