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Table 2 Summary of studies of dantrolene treatment of heat stroke in animals

From: Clinical review: Treatment of heat stroke: should dantrolene be considered?

Reference Study type Model Numbers included Dantrolene dose (mg/kg bw) Improved parameters Nonimproved parameters
[18] Randomized controlled Exercising rats 7 140 Cooling rate -
   Nonexercising rats 7 140 - Cooling rate
[19] Randomized controlled Nonexercising piglets 4 3 Cooling ratea Cardivascular parameters
[16] Randomized controlled Nonexercising dogs 5 5 - Cooling rate, haemodynamic parameters, pathological changes, clinical outcome
  1. aImprovement was reported with or without mannitol. bw, Body weight