Table 2 Summary of studies of dantrolene treatment of heat stroke in animals
From: Clinical review: Treatment of heat stroke: should dantrolene be considered?
Reference | Study type | Model | Numbers included | Dantrolene dose (mg/kg bw) | Improved parameters | Nonimproved parameters |
|---|---|---|---|---|---|---|
[18] | Randomized controlled | Exercising rats | 7 | 140 | Cooling rate | - |
| Â | Â | Nonexercising rats | 7 | 140 | - | Cooling rate |
[19] | Randomized controlled | Nonexercising piglets | 4 | 3 | Cooling ratea | Cardivascular parameters |
[16] | Randomized controlled | Nonexercising dogs | 5 | 5 | - | Cooling rate, haemodynamic parameters, pathological changes, clinical outcome |