Science review: Searching for gene candidates in acute lung injury

Table 2 Candidate genes in acute lung injury

		Gene Ontology					PubMatrix terms
Encoded protein	Gene symbol	NR	IM	CT	IN	BC	Lung	Lung injury
Interleukin-1ß	IL1B	×	×		×		1536	287
Interleukin-6	IL6	×					963	173
Tissue factor precursor	TF		×			×	411	54
Plasminogen activator inhibitor-1	PAI1					×	201	31
Cyclo-oxygenase-2	COX2				×		257	28
Interleukin-13	IL13		×		×		327	21
Vitronectin	?VNT		×				138	11
Macrophage stimulatory protein	?MSP					×	102	11
Plasminogen activator, urokinase receptor	PLAUR			×		×	83	8
Tissue-type plasminogen activator	PLAT					×	101	7
Fibrinogen a	FGA					×	22	4
CCAAT/enhancer binding protein beta	CEBPB				×		27	3
Proteinase activated receptor 2	PAR-2					×	35	2
Plasma prekallikrein	?KLKB1				×	×	22	2
Cell chemokine 2 (MCP-1)	CCL2			×	×		11	1
Interleukin-8 receptor	IL8R			×	×		11	1
Chemokine CXC ligand 2 (MIP-2 alpha)	CXCL2		×	×	×		4	1
CC chemokine receptor 5 (CD 195)	CCR5			×	×		3	1
Annexin I	ANXA1				×		56	0
Eosinophil granule major basic protein	EBMP		×		×		56	0
Guanine nucleotide-binding protein 2	GBP2		×				38	0
Cathepsin C	CTSC		×				17	0
Interleukin-1 receptor type II	IL1R2		×				11	0
Cyclin-dependent kinase inhibitor 1 (p21)	CDKN1A	×					8	0
B-cell translocation gene 2	BTG2	×					3	0
B-cell translocation gene 1	BTG1	×					2	0
Type-2 phosphatidic acid phosphohydrolase	PAP2	×					1	0
Insulin-like growth factor binding protein 6	?IGFBP6	×					1	0
CXC chemokine receptor type 4 (LESTR)	CXCR4		×	×	×		0	0
XC chemokine ligand 1 (lymphotactin)	XCL1		×	×			0	0
Allograft inflammatory factor-1	AIF1	×			×		0	0
Linker for activation of T cells	LAT		×				0	0
B-cell antigen receptor complex protein	?CD79B		×				0	0

Abbreviation in parenthesis represents the old cytokine nomenclature. The '×' symbol designates gene ontology bioprocesses in which a given gene is involved. Numbers in PubMatrix terms columns represent citations containing the terms 'lung' and 'lung injury' terms. The '?' symbol indicates downregulated genes; all genes with unmarked gene names are upregulated. BC, blood coagulation; CT, chemotaxis; IM, immune response; IN, inflammatory response; NR, negative regulation of cell proliferation.

ISSN: 1364-8535