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Table 2 Candidate genes in acute lung injury

From: Science review: Searching for gene candidates in acute lung injury

   Gene Ontology PubMatrix terms
Encoded protein Gene symbol NR IM CT IN BC Lung Lung injury
Interleukin-1ß IL1B × ×   ×   1536 287
Interleukin-6 IL6 ×      963 173
Tissue factor precursor TF   ×    × 411 54
Plasminogen activator inhibitor-1 PAI1      × 201 31
Cyclo-oxygenase-2 COX2     ×   257 28
Interleukin-13 IL13   ×   ×   327 21
Vitronectin ?VNT   ×     138 11
Macrophage stimulatory protein ?MSP      × 102 11
Plasminogen activator, urokinase receptor PLAUR    ×   × 83 8
Tissue-type plasminogen activator PLAT      × 101 7
Fibrinogen a FGA      × 22 4
CCAAT/enhancer binding protein beta CEBPB     ×   27 3
Proteinase activated receptor 2 PAR-2      × 35 2
Plasma prekallikrein ?KLKB1     × × 22 2
Cell chemokine 2 (MCP-1) CCL2    × ×   11 1
Interleukin-8 receptor IL8R    × ×   11 1
Chemokine CXC ligand 2 (MIP-2 alpha) CXCL2   × × ×   4 1
CC chemokine receptor 5 (CD 195) CCR5    × ×   3 1
Annexin I ANXA1     ×   56 0
Eosinophil granule major basic protein EBMP   ×   ×   56 0
Guanine nucleotide-binding protein 2 GBP2   ×     38 0
Cathepsin C CTSC   ×     17 0
Interleukin-1 receptor type II IL1R2   ×     11 0
Cyclin-dependent kinase inhibitor 1 (p21) CDKN1A ×      8 0
B-cell translocation gene 2 BTG2 ×      3 0
B-cell translocation gene 1 BTG1 ×      2 0
Type-2 phosphatidic acid phosphohydrolase PAP2 ×      1 0
Insulin-like growth factor binding protein 6 ?IGFBP6 ×      1 0
CXC chemokine receptor type 4 (LESTR) CXCR4   × × ×   0 0
XC chemokine ligand 1 (lymphotactin) XCL1   × ×    0 0
Allograft inflammatory factor-1 AIF1 ×    ×   0 0
Linker for activation of T cells LAT   ×     0 0
B-cell antigen receptor complex protein ?CD79B   ×     0 0
  1. Abbreviation in parenthesis represents the old cytokine nomenclature. The '×' symbol designates gene ontology bioprocesses in which a given gene is involved. Numbers in PubMatrix terms columns represent citations containing the terms 'lung' and 'lung injury' terms. The '?' symbol indicates downregulated genes; all genes with unmarked gene names are upregulated. BC, blood coagulation; CT, chemotaxis; IM, immune response; IN, inflammatory response; NR, negative regulation of cell proliferation.