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Table 2 Summary of effects of lactic acid versus HCl on lipopolysaccharide-stimulated RAW 264.7 cells

From: Science review: Extracellular acidosis and the immune response: clinical and physiologic implications

 

Lactic acid (pH 7.0)

Lactic acid (pH 6.5)

HCl (pH 7.0)

HCl (pH 6.5)

NO

↓

↓↓

↑

-

iNOS mRNA

↓

↓↓

↑

↑↑

IL-6

↓

↓↓

-

↓

IL-6 mRNA

↓

↓↓

-

↓

IL-10

↓

↓↓

↓

↓↓↓

IL-10 mRNA

↓↓

↓↓

-

-

IL-6 : IL-10 ratio

-

-

-

↑↑

NF-κB

↓

↓↓

↑

↓

  1. IL, interleukin; iNOS, inducible nitric oxide synthase; NO, nitric oxide. Adapted from Kellum and coworkers [19].