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Table 2 Summary of effects of lactic acid versus HCl on lipopolysaccharide-stimulated RAW 264.7 cells

From: Science review: Extracellular acidosis and the immune response: clinical and physiologic implications

  Lactic acid (pH 7.0) Lactic acid (pH 6.5) HCl (pH 7.0) HCl (pH 6.5)
NO ↓↓ -
iNOS mRNA ↓↓ ↑↑
IL-6 ↓↓ -
IL-6 mRNA ↓↓ -
IL-10 ↓↓ ↓↓↓
IL-10 mRNA ↓↓ ↓↓ - -
IL-6 : IL-10 ratio - - - ↑↑
NF-κB ↓↓
  1. IL, interleukin; iNOS, inducible nitric oxide synthase; NO, nitric oxide. Adapted from Kellum and coworkers [19].