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Table 5 Exposure to opioids and sedatives

From: Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Parameter Remifentanil (n = 84) Fentanyl (n = 37) Morphine (n = 40)
Opioid    
   Median duration of opioid infusion, h (range) 47.3 (3.8–120) 35.2 (0.2–120) 40.9 (4.5–120)
   Median weighted mean opioid infusion rate: remifentanil and fentanyl, μg kg-1 h-1; morphine, mg kg-1 h-1 (range) 15.4 (3.0–38.2) 3.6 (0.1–7.9) 0.1 (0.0–6.8)
Propofol    
   Number of patients who received a propofol infusion 76 (90%) 37 (100%) 37 (93%)
   Median duration of propofol infusion, h (range) 24.3 (0.0–118) 24.5 (0.0–119.4) 41.7 (0.7–115.3)
   Median weighted mean propofol infusion rate, mg kg-1 h-1 (range) 1.93 (0.2–68.8) 2.49 (0.5–11.5) 2.30 (0.3–18.1)
Midazolam    
   Number of patients who received a midazolam infusion 30 (36%) 11 (30%) 12 (30%)
   Median duration of midazolam infusion, h (range) 47.3 (0–117.1) 48.1 (2.3–112.1) 22.4 (1.8–101.4)
   Median weighted mean midazolam infusion rate, mg kg-1 h-1 (range) 0.18 (0–17) 0.11 (0–2.3) 0.13 (0.1–0.5)