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Table 3 Time to and variability around individual neurological assessment

From: Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Parameter Overall Day 1 Day 2 Day 3 Day 4 Day 5
Remifentanil n = 64 n = 58 n = 33 n = 26 n = 21 n = 20
   Mean time to neurological assessment,a h 0.41 0.35 0.45 0.46 0.78 0.81
   Between-patient variability 0.44 0.35 0.47 1.35 0.30 0.42
Fentanyl n = 32 n = 32 n = 13 n = 11 n = 7 n = 8
   Mean time to neurological assessment,a h 0.71 0.69 0.67 0.92 1.63 1.83
Mean ratio (95% CI) 1.74 (1.26, 2.41) 1.98 (1.44, 2.72) 1.48 (0.73, 3.01) 2.01 (0.93, 4.33) 2.09 (1.33, 3.30) 2.27 (1.39, 3.73)
Remifentanil versus fentanyl P = 0.001 P < 0.001 P = 0.274 P = 0.074 P = 0.003 P = 0.002
   Between-patient variability 0.86 0.86 3.01 0.51 0.13 0.10
Ratio of variability (95% CI) 1.96 (1.01, 3.45) 2.45 (1.37, 4.79) 6.41 (2.83, 19.9) 0.38 (0.15, 1.34) 0.45 (0.16, 2.61) 0.24 (0.08, 1.16)
Remifentanil versus fentanyl P = 0.024 P = 0.003 P < 0.001 P = 0.109 P = 0.333 P = 0.059
Morphine n = 34 n = 31 n = 20 n = 10 n = 3 n = 2
   Mean time to neurological assessmenta, h 0.82 0.79 0.70 1.01 1.28 1.86
Mean ratio (95% CI) 2.01 (1.44, 2.81) 2.25 (1.60, 3.15) 1.53 (0.93, 2.52) 2.19 (0.98, 4.86) 1.65 (0.84, 3.25) 2.31 (0.87, 6.13)
Remifentanil versus morphine P < 0.001 P < 0.001 P = 0.091 P = 0.055 P = 0.139 P = 0.088
   Between-patient variability 0.98 1.03 1.27 0.48 0.12 0.02
Ratio of variability (95% CI) 2.24 (1.28, 4.28) 2.93 (1.63, 5.80) 2.71 (1.27, 6.58) 0.35 (0.14, 1.37) 0.41 (0.13, 23.0) 0.06 (0.02, 112.6)
Remifentanil versus morphine P = 0.006 P = 0.001 P = 0.012 P = 0.108 P = 0.659 P = 0.381
  1. Between-patient variability is a measure of predictability of wake-up for neurological assessment. CI, confidence interval. aGeometric mean.