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Table 2 Patient characteristics and baseline clinical assessments

From: Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Characteristic Remifentanil Fentanyl Morphine
Number of patients treated 84 37 40
Mean age, years (SD) 46.8 (16.3) 49.6 (16.9) 47.3 (20.0)
Sex    
   Male 44 (52%) 24 (65%) 25 (63%)
   Female 40 (48%) 13 (35%) 15 (38%)
Mean height, cm (SD) 171.1 (9.1) 170.9 (7.4) 170.9 (8.5)
Mean weight, kg (SD) 76.5 (12.2) 76.5 (12.6) 75.2 (12.2)
Median duration of mechanical ventilation, days (range) 1.95 (0.16–5.00) 1.47 (0.08–5.00) 1.70 (0.19–5.00)
Reason for admission to ICU    
   Subarachnoid haemorrhage 19 (23%) 7 (19%) 12 (30%)
   Isolated neurotrauma 13 (15%) 4 (11%) 9 (23%)
   Post-intracranial surgery 31 (37%) 18 (49%) 10 (25%)
   Epidural, subdural or intracranial haematoma 16 (19%) 6 (16%) 6 (15%)
   Cerebrovascular accidentsa 3 (4%) 1 (3%) 2 (5%)
   Other 2 (2%) 1 (3%) 1 (3%)
Mean SAS score (SD) 3.7 (1.5) 3.6 (1.2) 3.7 (1.5)
Mean GCS (SD) 8.4 (2.7) 8.8 (2.9) 8.6 (2.5)
Mean Pain Intensity score (SD) 2.1 (1.1) 2.1 (1.0) 2.1 (1.0)
Mean MAP, mmHg (SD) 97.2 (17.6) 100.6 (13.8) 97.4 (14.1)
Mean heart rate, bpm (SD) 89.3 (20.3) 90.9 (20.5) 88.9 (21.5)
  1. bpm, beats per minute, GCS, Glasgow Coma Score; ICU, intensive care unit; MAP, mean arterial pressure; SAS, Sedation–Agitation Scale; SD, standard deviation. aResuscitation owing to cardiac disease; treatment with interventional radiology for cerebral disorders; meningitis; encephalitis.