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Table 2 Role of CD18 integrins for neutrophil recruitment in different rodent and rabbit models of acute lung injury

From: Bench-to-bedside review: Acute respiratory distress syndrome – how neutrophils migrate into the lung

CD18 dependency

Stimulus

Dependent

Escherichia coli

 

Pseudomonas aeruginosa

 

E. coli endotoxin (intratracheally administered)

 

Cobra venom factor

 

Hydrochloric acid (contralateral lung)

 

IgG immune complex

 

IL-1

Independent

Streptococcus pneumoniae

 

Group B streptococcus

 

Staphylococcus aureus

 

E. coli endotoxin (systemically administered)

 

Hydrochloric acid (site of installation)

 

Hyperoxia

 

Complement protein C5a

  1. IL, interleukin.