From: Clinical review: Immunomodulatory effects of dopamine in general inflammation
Influence on | Â | Effect | Mechanism |
---|---|---|---|
Pituitary hormones: | Prolactin | Suppression | Indirectly via nNOS, D2 receptor |
 | Thyroid hormones | Suppression | D2 receptor |
 | Growth hormones | Suppression | D2 receptor |
 | Glucocorticoid | Induction | α2 receptor, D2 receptor |
Cytokines: | IL-10 | Induction | β receptor, ROS |
 | TNF-α (monocytes, HUVECs) | Suppression | β receptor, ROS |
 | TNF-α (neutrophils) | Suppression | D1 receptor |
 | IL-1 | Suppression | β receptor, ROS |
 | IL-6 (monocytes, HUVECs) | Suppression | β receptor, ROS |
 | IL-6 (glomerulosa cells) | Induction | D2 receptor |
 | IL-12 p40 | Suppression | β receptor |
Chemokines: | IL-8 (HUVEC) | Induction | ROS |
 | IL-8 (PTEC) | Suppression | ROS |
 | Gro-α | Suppression | ROS |
 | ENA-78 | Suppression | ROS |
Adhesion molecules | CD11b/CD18 | Suppression | ROS |
 | E-selectin | Suppression | ROS? |
 | ICAM-1 | Suppression | ROS? |
Nitric oxide | In HUVECs | Suppression | ROS |
 | In monocytes | Induction | β receptor |
Apoptosis | In neutrophils | Induction | D1 and β receptor, ROS |
 | In lymphocytes | Induction | D1 and β receptor, ROS |
PLA2 metabolites: | PAF | Suppression | ? |
Respiratory burst | In neutrophils | Suppression | D1 receptor |