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Table 1 Drug related glucocorticoid insufficiency
| Mechanisms | Drugs |
|---|---|
| Primary adrenal insufficiency | |
| Haemorrhage | Anticoagulant therapy (heparin, warfarin) |
| Cortisol synthesis enzyme inhibition | Aminogluthethimide |
| Ketoconazole | |
| Fluconazole | |
| Etomidate | |
| Dexmedetomidine | |
| Cortisol metabolism activation | Phenobarbital |
| Phenytoin | |
| Rifampin | |
| Secondary adrenal insufficiency | |
| Suppression of CRH and ACTH synthesis | Glucocorticoid therapy (systemic or topical) |
| Megestrol acetate | |
| Medroxyprogesterone | |
| Ketorolac tromethamine | |
| Antidepressant drugs (e.g. imipramine) | |
| Opiate drugs | |
| Peripheral resistance to glucocorticoids | |
| Interaction with glucocorticoids receptor | Mifepristone |
| Inhibition of the glucocorticosteroid-induced gene transcription | Antipsychotic drugs (e.g. chlorpromazine) |
| Antidepressant drugs (e.g. imipramine) |
