Mechanisms | Drugs |
---|---|
Primary adrenal insufficiency | Â |
   Haemorrhage | Anticoagulant therapy (heparin, warfarin) |
   Cortisol synthesis enzyme inhibition | Aminogluthethimide |
 | Ketoconazole |
 | Fluconazole |
 | Etomidate |
 | Dexmedetomidine |
   Cortisol metabolism activation | Phenobarbital |
 | Phenytoin |
 | Rifampin |
Secondary adrenal insufficiency | Â |
   Suppression of CRH and ACTH synthesis | Glucocorticoid therapy (systemic or topical) |
 | Megestrol acetate |
 | Medroxyprogesterone |
 | Ketorolac tromethamine |
 | Antidepressant drugs (e.g. imipramine) |
 | Opiate drugs |
Peripheral resistance to glucocorticoids | Â |
   Interaction with glucocorticoids receptor | Mifepristone |
   Inhibition of the glucocorticosteroid-induced gene transcription | Antipsychotic drugs (e.g. chlorpromazine) |
 | Antidepressant drugs (e.g. imipramine) |