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Table 1 Drug related glucocorticoid insufficiency

From: Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids

Mechanisms Drugs
Primary adrenal insufficiency  
   Haemorrhage Anticoagulant therapy (heparin, warfarin)
   Cortisol synthesis enzyme inhibition Aminogluthethimide
  Ketoconazole
  Fluconazole
  Etomidate
  Dexmedetomidine
   Cortisol metabolism activation Phenobarbital
  Phenytoin
  Rifampin
Secondary adrenal insufficiency  
   Suppression of CRH and ACTH synthesis Glucocorticoid therapy (systemic or topical)
  Megestrol acetate
  Medroxyprogesterone
  Ketorolac tromethamine
  Antidepressant drugs (e.g. imipramine)
  Opiate drugs
Peripheral resistance to glucocorticoids  
   Interaction with glucocorticoids receptor Mifepristone
   Inhibition of the glucocorticosteroid-induced gene transcription Antipsychotic drugs (e.g. chlorpromazine)
  Antidepressant drugs (e.g. imipramine)
  1. ACTH, adrenocorticotrophic hormone; CRH, corticotropin-releasing hormone.