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Table 2 Procalcitonin (PCT), C-reactive protein (CRP), and lactate plasma levels at various severities of organ dysfunction, categorised according to four groups of the sequential organ failure assessment (SOFA) score, comparing patients with and without infection and trauma

From: Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction

Category of SOFA score (number of observations, noninfected/infected) Noninfected Infected P, noninfected /infected Trauma (number of trauma observations)
PCT (ng/ml)     
   1–6 (n = 180/377) 0.14 (0.08/0.33) 0.62 (0.24/2.12) < 0.001 0.25 (0.08–0.9) (n = 368)
   7–12 (n = 24/132) 0.25 (0.2/0.3) 2.43 (1.2/8.68) < 0.001 5.54 (0.86–12.87) (n = 88)
   13–18 (n = 1/30) 0.41 8.5 (3.39/29.59) n.s. 54 (15.58–122.4) (n = 9)
   19–24 (n = 0/13) - 23.24 (2.28/50.9) - -
   Pearson's correlation 0.108 (P = n.s.) 0.247 (P < 0.001)   0.465 (P <0.001)
   Regression, y = a + bx 0.27 + 0.02 × SOFA score -0.84 + 1.526 × SOFA score < 0.02 -5 + 2.16 × SOFA score
CRP (mg/l)     
   1–6 (n = 180/377) 68 (28/121) 121 (68/176) < 0.001 91 (49.8–148) (n = 368)
   7–12 (n = 24/132) 47(15/81) 181 (78/271) < 0.001 110 (64–151) (n = 88)
   13–18 (n = 1/30) 12.3 183 (128/219) n.s. 94 (n = 9)
   19–24 (n = 0/13) - 154 (9.6/308) - -
   Pearson's correlation 0.069 (P = n.s.) 0.286 (P < 0.001)   0.095 (P = n.s.)
   Regression, y = a + bx 84.53 - 0.19 × SOFA score 105.58 + 0.72 × SOFA score < 0.001 95 + 0.24 × SOFA score
Lactate (mmol/l)     
   1–6 (n = 180/377) 1.21 (0.96/1.44) 1.3 (1.04/1.69) n.s. 1.1 (0.86–1.51) (n = 368)
   7–12 (n = 24/132) 1.55 (1.22/3.54) 1.69 (1.2/2.2) n.s. 2.09(1.19–2.61) (n = 88)
   13–18 (n = 1/30) 2.8 3.07 (2.25/3.59) n.s. 5.58 (n = 9)
   19–24 (n = 0/13) - 3.69 (3.52/5) - -
   Pearson's correlation 0.350 (P < 0.002) 0.382 (P < 0.001)   0.431 (P <0.001)
   Regression, y = a + bx 0.918 + 0.14 × SOFA score 0.968 + 0.12 × SOFA score n.s. 0.516 + 0.235 × SOFA score
  1. Data presented as median values (lower and upper quartiles). P value from Mann–Whitney U-test.