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Table 2 Selected studies of anti-inflammatory effects of beta agonists in acute lung injury

From: Science review: Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema

Study

Model

Treatment

Effect

Perkins and colleagues, 2003 [54]

Human neutrophils

Salbutamol

Inhibited chemotaxis

Sekut and colleagues, 1995 [47]

Lipopolysaccharide-activated THP1 cells

Salmeterol, salbutamol

Inhibited TNF-α

Dhingra and colleagues, 2001 [46]

Murine sepsis

Dobutamine, dopexamine

Attenuated inflammatory cytokine expression and chemokines induction

Van der Poll and colleagues, 1994 [48]

Lipopolysaccharide-stimulated macrophages

Norepinephrine

Decreased TNF-α, IL-6

Van der Poll and Lowry, 1997 [49]

Human endotoxemia

Epinephrine

Increased IL-10

  1. TNF-α, tumor necrosis factor alpha.
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Critical Care

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