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Table 1 Selected studies of alveolar fluid clearance by beta agonists

From: Science review: Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema

Study Model Beta-2 agonist Effect
Sartori and colleagues, 2002 [43] High-altitude edema in humans Salmeterol +
Ware and colleagues, 2002 [61] Human donor lung Terbutaline +
Sakuma and colleagues, 1994 [29] Resected human lung Terbutaline +
Atabai and colleagues, 2002 [45] Ventilated patients (ARDS) Albuterol +
Sakuma and colleagues, 1997 [62] Ex vivo human and rat Salmeterol +
Suzuki and colleagues, 1995 [63] Cultured rat alveolar type II Terbutaline +
Minakata and colleagues, 1998 [36] Cultured rat alveolar type II Terbutaline +
Planes and colleagues, 2002 [37] Cultured rat alveolar type II Terbutaline +
Icard and Saumon, 1999 [64] Mice Terbutaline +
Tibayan and colleagues, 1997 [27] Rats Dobutamine +
Barnard and colleagues, 1997 [28] Rats Dopamine +
Charron and colleagues, 1999 [65] Rats Epinephrine +
Saldias and colleagues, 1999 [34] Rats Isoproterenol +
Morgan and colleagues, 2002 [39] Rats Prolonged isoproterenol -
Lasnier and colleagues, 1996 [66] Rats Terbutaline +
Norlin and colleagues, 2001 [31] Rats Terbutaline +
Jayr and colleagues, 1994 [30] Rats Terbutaline +
Saldias and colleagues, 2000 [67] Rats Terbutaline + isoproterenol +
Pittet and colleagues, 1994 [12] Rats Epinephrine +
  Rabbit Epinephrine -
Smedira and colleagues, 1991 [68] Rabbit Terbutaline -
Effros and colleagues, 1987 [69] Rabbit Terbutaline -
Campbell and colleagues, 1999 [70] Sheep Salmeterol +
Berthiaume and colleagues, 1987 [71] Sheep Terbutaline +
Berthiaume and colleagues, 1988 [72] Sheep (faster) > dog Terbutaline +
Frank and colleagues, 2000 [35] Sheep and rats Salmeterol +
Grimme and colleagues, 1997 [73] Dogs Terbutaline +
Sugita and colleagues, 2003 [74] Transplanted dogs Terbutaline -
  1. ARDS, acute respiratory distress syndrome; +, increased alveolar edema clearance; -, no effect.