Skip to main content

Advertisement

Table 2 Physiologic markers of renal function

From: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

Specific for Measurable Acceptable?1 Realistic/time-related?2
GFR PAH No No
  Creatinine Yes Yes
  Creatinine clearance 2-hour: yes Yes
   24-hour: yes No
  BUN Yes Yes
  Inulin clearance Yes No
  Iohexol/iopromide Yes Yes
  Iothalmate Yes Yes
  I131-MAG Yes No
  Cr52-EDTA Yes No
Renal blood flow Angiography Yes No
  Indicator dilution (thermal or PAH) Yes No
  BOLD MRI Yes No
  Ultrasound Yes Yes
Tubular function Urine output Yes Yes
  Input-output balance Yes Yes
  Urinalysis Yes Yes
  FeNa Yes Yes
  Osmolality Yes Yes
  Creatinine (U/P) Yes Yes
  Tubular proteins No No
  1. 1The term 'acceptable' refers to the consensus view that each one of these tests represents a marker that reflects the function being measured with sufficient specificity and sensitivity for experimental and clinical use. 2The term 'realistic' refers to consensus of the current feasibility of using such markers in clinical practice. BOLD, blood oxygenation level dependent; BUN, blood urea nitrogen; MRI, magnetic resonance imaging; PAH, para-aminohippuric acid; U/P, urine/plasma.