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Table 2 Physiologic markers of renal function

From: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

Specific for

Measurable

Acceptable?1

Realistic/time-related?2

GFR

PAH

No

No

 

Creatinine

Yes

Yes

 

Creatinine clearance

2-hour: yes

Yes

  

24-hour: yes

No

 

BUN

Yes

Yes

 

Inulin clearance

Yes

No

 

Iohexol/iopromide

Yes

Yes

 

Iothalmate

Yes

Yes

 

I131-MAG

Yes

No

 

Cr52-EDTA

Yes

No

Renal blood flow

Angiography

Yes

No

 

Indicator dilution (thermal or PAH)

Yes

No

 

BOLD MRI

Yes

No

 

Ultrasound

Yes

Yes

Tubular function

Urine output

Yes

Yes

 

Input-output balance

Yes

Yes

 

Urinalysis

Yes

Yes

 

FeNa

Yes

Yes

 

Osmolality

Yes

Yes

 

Creatinine (U/P)

Yes

Yes

 

Tubular proteins

No

No

  1. 1The term 'acceptable' refers to the consensus view that each one of these tests represents a marker that reflects the function being measured with sufficient specificity and sensitivity for experimental and clinical use. 2The term 'realistic' refers to consensus of the current feasibility of using such markers in clinical practice. BOLD, blood oxygenation level dependent; BUN, blood urea nitrogen; MRI, magnetic resonance imaging; PAH, para-aminohippuric acid; U/P, urine/plasma.