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Table 1 Markers of candidate genes used for association studies in sepsis

From: Bench-to-bedside review: Understanding genetic predisposition to sepsis

Gene Marker Association Reference
BPI Lys-Glu (216) - [28]
BPI Noncoding PstI - [28]
BPI Synonymous TaqI (545) - [28]
HSP70-2 Coding PstI (position?) - [38]
HSP70-HOM Met-Thr (493) - [38]
LBP Cys-Gly (98) + (male) [28]
LBP Leu-Pro (436) - [28]
LBP Synonymous HpaII (291) - [29]
MBL Exon 1 (codons 52, 54, 57) + [25]
CD14 -260 (-159) promoter - [31, 32]
TLR-4 Asp-Gly (299) + [34, 35]
TLR-4 Thr-Ile (399) - [35]
TLR-4 Rare coding mutations + [36]
TLR-2 Arg-Gln (753) + [39]
TLR-2 Rare coding mutations - [36]
FCγRIIa His-Arg (131) + [40]
Angiotensin-converting enzyme Noncoding indela + [41]
Factor V Leiden Arg-Gln (506) + [42]
Plasminogen activator inhibitor-1 Promoter single base indela + [43]
Tissue-type plasminogen activator Noncoding indela - [44]
IL-1 receptor antagonist Noncoding microsatellite + [27]
IL-1β Synonymous TaqI (297) - [27]
IL-6 -174 promoter - [45]
IL-10 -1082 promoter + [40]
TNF-α -308 promoter + [23]
TNF-β (LTA) Noncoding Nco I + [27, 46]
  1. BPI, bactericidal/permeability-increasing protein; FcgRIIa, immunoglobulin G Fc receptor II; HSP, heat shock protein; LBP, lipopolysaccharide-binding protein; LTA, lymphotoxin-alpha; MBL, mannose-binding lectin; TLR, Toll-like receptor; TNF, tumor necrosis factor. a Insertion/deletion.