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Table 2 Effects of candesartan in six dogs

From: Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs

Parameter

Baseline

Candesartan

FiO2

0.4

0.1

0.4

0.1

Q (l/min per m2)

4.1 ± 0.1

4.3 ± 0.3

4.05 ± 0.1

4.4 ± 0.3

Ppa (mmHg)

12 ± 1

21 ± 1*

12 ± 1

22 ± 2*

Ppao (mmHg)

4 ± 1

3 ± 1

4 ± 1

3 ± 1

Psa (mmHg)

121 ± 3

126 ± 4

101 ± 2 +

116 ± 5†

HR (beats/min)

123 ± 8

157 ± 8*

115 ± 6 +

145 ± 8*

pHa

7.39 ± 0.01

7.40 ± 0.01

7.38 ± 0.01

7.38 ± 0.01

PaO2 (mmHg [kPa])

271 ± 4 (36 ± 0.5)

31 ± 3* (4 ± 0.4)

254 ± 4 (34 ± 0.5)

27 ± 3* (3 ± 0.4)

PaCO2 (mmHg [kPa])

37 ± 1 (5 ± 0.1)

37 ± 1 (5 ± 0.1)

38 ± 1 (5 ± 0.1)

38 ± 1 (5 ± 0.1)

PvO2 (mmHg [kPa])

52 ± 1 (7 ± 0.1)

22 ± 2* (3 ± 0.3)

50 ± 2 (7 ± 0.3)

21 ± 1* (3 ± 0.1)

  1. Data are presented as mean ± standard error of the mean. FiO2, fraction of inspired oxygen; HR, heart rate; PaCO2, carbon dioxide tension in arterial blood; PaO2, oxygen tension in arterial blood; pHa, arterial pH; Ppa, mean pulmonary artery pressure; Ppao, pulmonary artery occluded pressure; Pra, right atrial pressure; Psa, mean systemic artery pressure; PvO2, oxygen tension in mixed venous blood; Q, cardiac index. *P < 0.01 versus FiO2 0.4, same drug condition; †P < 0.01 versus baseline, same FiO2.
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Critical Care

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