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Table 1 Effects of enalaprilat in 10 dogs

From: Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs

Parameter

Baseline

Enalaprilat

FiO2

0.4

0.1

0.4

0.1

Q (l/min per m2)

3.4 ± 0.1

3.5 ± 0.2

3.5 ± 0.1

3.4 ± 0.1

Ppa (mmHg)

14 ± 1

24 ± 2*

15 ± 2

28 ± 2*†

Ppao (mmHg)

6 ± 1

5 ± 1

5 ± 1

6 ± 1

Psa (mmHg)

119 ± 4

123 ± 8

101 ± 3†

102 ± 10†

HR (beats/min)

169 ± 6

189 ± 8*

166 ± 5

183 ± 8*

pHa

7.34 ± 0.01

7.37 ± 0.01

7.34 ± 0.01

7.36 ± 0.02

PaO2 (mmHg [kPa])

172 ± 15 (23 ± 2)

30 ± 2* (4 ± 0.3)

168 ± 12 (22 ± 2)

29 ± 1* (4 ± 0.1)

PaCO2 (mmHg [kPa])

38 ± 1 (5 ± 0.1)

37 ± 1 (5 ± 0.1)

37 ± 1 (5 ± 0.1)

37 ± 1 (5 ± 0.1)

PvO2 (mmHg [kPa])

50 ± 2 (7 ± 0.1)

20 ± 2* (3 ± 0.3)

50 ± 2 (7 ± 0.3)

19 ± 2* (3 ± 0.3)

  1. Data are presented as mean ± standard error of the mean. FiO2, fraction of inspired oxygen; HR, heart rate; PaCO2, carbon dioxide tension in arterial blood; PaO2, oxygen tension in arterial blood; pHa, arterial pH; Ppa, mean pulmonary artery pressure; Ppao, pulmonary artery occluded pressure; Pra, right atrial pressure; Psa, mean systemic artery pressure; PvO2, oxygen tension in mixed venous blood; Q, cardiac index. *P < 0.01 versus FiO2 0.4, same drug condition; †P < 0.01 versus baseline, same FiO2.
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Critical Care

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