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Table 1 Hemodynamic response to volume loading in echocardiographically studied group (group 1)

From: Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study

Parameter

Before saline infusion

After saline infusion

Percentage change

P

HR (beats/min)

64.4 ± 1.8

64.1 ± 2.0

-0.02 ± 1.9

NS

SBP (mmHg)

115.4 ± 2.2

115.2 ± 2.7

-0.1 ± 1.9

NS

DBP (mmHg)

59.3 ± 1.8

57.3 ± 1.8

-3.5 ± 1.5

NS

MAP (mmHg)

80.7 ± 1.8

79.6 ± 1.9

-1.2 ± 1.3

NS

TPR (dyne·s/cm5)

599 ± 25

491 ± 27

-17.8 ± 3.8

<0.0001

CI (l/min per m2)

2.90 ± 0.07

3.32 ± 0.09

14.7 ± 2.4

<0.0001

SVI (ml/m2)

47.5 ± 1.0

54.3 ± 1.2

14.6 ± 1.4

<0.0001

LVEDVI (ml/m2)

72.2 ± 1.8

72.7 ± 1.7

1.0 ± 1.3

NS

LVESVI (ml/m2)

24.6 ± 1.3

17.9 ± 1.0

-26.4 ± 2.4

<0.0001

LVEF (%)

65.5 ± 1.2

74.5 ± 1.0

14.0 ± 1.4

<0.0001

SBP/LVESVI (mmHg/ml per m2)

5.00 ± 0.31

6.88 ± 0.41

40.2 ± 6.4

<0.0001

  1. CI, cardiac index; HR, heart rate; DBP, diastolic blood pressure; LVEDVI, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVI, left ventricular end-systolic volume index; MAP, mean arterial pressure; SBP, systolic blood pressure; SVI, stroke volume index; TPR, total peripheral resistance.