Skip to main content

Table 2 Median biomarker levels at baseline by quartile of Acute Physiology and Chronic Health Evaluation II score (n = 1690)

From: Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]

Biomarker

1st Quartile (median [95% CI])

2nd Quartile (median [95% CI])

3rd Quartile (median [95% CI])

4th Quartile (median [95% CI])

ρ

P

D-dimer (μg/ml)

3.84 (3.60–4.24)

3.93 (3.59–4.61)

4.11 (3.49–5.03)

5.03 (4.41–5.56)

0.10

<0.001a

IL-6 (pg/ml)

289 (245–369)

384 (322–489)

623 (494–829)

1043 (809–1613)

0.23

<0.001

Protein C (%)

0.52 (0.49–0.55)

0.48 (0.45–0.51)

0.50 (0.44–0.53)

0.42 (0.40–0.45)

-0.12

<0.001a

AT (%)

0.62 (0.60–0.65)

0.59 (0.57–0.62)

0.60 (0.57–0.63)

0.55 (0.53–0.57)

-0.11

<0.001

Protein S (%)

0.42 (0.36–0.47)

0.37 (0.33–0.41)

0.38 (0.33–0.46)

0.33 (0.30–0.35)

-0.07

0.006a

PT (seconds)

18.1 (17.6–18.4)

18.5 (18.0–19.0)

18.6 (18.2–19.0)

19.7 (19.1–20.1)

0.15

<0.001

APTT (seconds)

40.5 (39.9–42.3)

42.5 (40.9–43.9)

42.5 (40.3–43.6)

45.1 (43.4–46.4)

0.13

<0.001

Platelets (109/l)

184 (173–192)

182 (167–191)

185 (174–199)

179 (167–192)

-0.03

0.19

F1.2 (nmol/l)

1.65 (1.38–1.87)

1.83 (1.49–2.19)

2.09 (1.67–2.38)

1.60 (1.38–1.91)

0.04

0.49b

TAT (μg/l)

10.7 (9.3–13.8)

10.8 (9.1–13.4)

11.7 (10.1–16.3)

12.3 (9.9–14.8)

0.06

0.27

PAI-1 (AU/ml)

25 (21.0–33.0)

33 (28–38)

34 (26–40)

40 (36–55)

0.24

<0.001

TAFI (μg/ml)

4.4 (3.7–4.9)

4.3 (3.7–4.8)

4.5 (4.1–5.3)

5.4 (4.5–6.1)

0.12

0.03a

α2-AP (%)

103 (93–106)

93 (90–105)

96 (90–113)

95 (88–105)

-0.04

0.43

Plasminogen (%)

62.0 (57–69)

59.5 (52–65)

60.5 (58–67)

60.0 (55–70)

0.004

0.94

sTM (ng/ml)

61 (56–71)

62 (52–75)

83 (73–109)

91 (74–117)

0.29

<0.001

IL-1β (pg/ml)

≤10 (10–10)

≤10 (10–10)

≤10 (10–10)

≤10 (10–10)

0.06

0.26

IL-10 (pg/ml)

≤10 (10–10)

≤10 (10–10)

≤10 (10–30)

≤10 (10–27)

0.16

0.001

IL-8 (pg/ml)

50 (50–50)

50 (50–50)

50 (50–144)

117 (50–177)

0.21

<0.001

TNF-α (pg/ml)

≤10 (10–21)

22 (10–27)

21 (10–41)

28 (21–33)

0.17

0.005

  1. The quartiles of Acute Physiology and Chronic Health Evaluation (APACHE) II scores are as follows: 1st quartile, score 3–19; 2nd quartile, score 20–24; 3rd quartile, score 25–29; and 4th quartile, score 30–53. Spearman rank correlation (ρ) is between continuous values of APACHE with each biomarker. aNonsignificant correlation with APACHE if 4th quartile is deleted. bSignificant correlation with APACHE if 4th quartile is deleted. α2-AP, α2-antiplasmin; APTT, activated partial thromboplastin time; AT, antithrombin; CI, confidence interval; F1.2, prothrombin fragment 1.2; IL, interleukin; PAI, plasminogen activator inhibitor; PT, prothrombin time; TAFI, thrombin-activatable fibrinolysis inhibitor; sTM, soluble thrombomodulin; TAT, thrombin–antithrombin complex; TNF, tumor necrosis factor.
Back to article page

Critical Care

ISSN: 1364-8535