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Table 1 Characteristics of three hemoglobin-based oxygen carriers being tested in advanced clinical trials

From: Hemoglobin-based oxygen carriers

  Product name
Details PolyHeme® Hemopure® (HBOC-201) HemoLink™ (Hb-raffimer)
Company Northfield Laboratories (Evanston, IL, USA) Biopure Corporation (Cambridge, MA, USA) Hemosol Inc. (Toronto, Canada)
Modification method Pyridoxylation and glutaraldehyde polymerization (polymer) Glutaraldehyde polymerization (polymer) Crosslinking with o-raffinose (oligomer)
Hemoglobin source Human hemoglobin Bovine hemoglobin Human hemoglobin
Hemoglobin concentration (g/dl) 10 13 10
Molecular weight Not reported (< 64 kDa; 1.0%) Average molecular weight: 250 kDa <64 kDa: <5%
    64–500 kDa: >90%
    >500 kDa: <3%
pH Not reported 7.6–7.9 7.5
P50 (torr) 26–32 38 52
Viscosity (cP) Not reported 1.3 1.14
Shelf life >1 year >1 year >1 year
  1. HBOC, hemoglobin-based oxygen carrier; P50, partial pressure of oxygen at which hemoglobin is 50% saturated.