Table 1 Characteristics of three hemoglobin-based oxygen carriers being tested in advanced clinical trials
Product name | |||
|---|---|---|---|
Details | PolyHeme® | Hemopure® (HBOC-201) | HemoLink™ (Hb-raffimer) |
Company | Northfield Laboratories (Evanston, IL, USA) | Biopure Corporation (Cambridge, MA, USA) | Hemosol Inc. (Toronto, Canada) |
Modification method | Pyridoxylation and glutaraldehyde polymerization (polymer) | Glutaraldehyde polymerization (polymer) | Crosslinking with o-raffinose (oligomer) |
Hemoglobin source | Human hemoglobin | Bovine hemoglobin | Human hemoglobin |
Hemoglobin concentration (g/dl) | 10 | 13 | 10 |
Molecular weight | Not reported (< 64 kDa; 1.0%) | Average molecular weight: 250 kDa | <64 kDa: <5% |
64–500 kDa: >90% | |||
>500 kDa: <3% | |||
pH | Not reported | 7.6–7.9 | 7.5 |
P50 (torr) | 26–32 | 38 | 52 |
Viscosity (cP) | Not reported | 1.3 | 1.14 |
Shelf life | >1 year | >1 year | >1 year |