N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report

Table 1 Patient data: basic patient characteristics, scores, hemodynamic-related parameters, and laboratory parameters

	Patient 1		Patient 2		Patient 3		Patient 4		Patient 5
Sex	Male		Male		Female		Male		Male
Age (years)	66		74		84		61		47
Sepsis source	Pneumonia		Pneumonia/urosepsis		Peritonitis		Peritonitis		Peritonitis
Survivor	Yes		Yes		No		Yes		Yes
N-acetylcysteine	Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post
APACHE II (points)	27	24	26	23	24	22	26	21	22	20
MOD score (points)	9	11	11	9	11	11	9	9	7	5
HR (beats/min)	121	122	100	102	116	118	119	100	62	76
MAP (mmHg)	98	90	86	83	88	74	71	83	80	74
CI (l/min/m²)	3.4	3.8	3.7	4.3	3.0	3.8	4.2	4.5	7.0	6.1
NE (μg/kg/min)	0.09	0.14	0.47	0.47	0.64	1.27	0.48	0.48	0.05	0.00
PaO₂/FiO₂ (Torr)	307	217	260	151	314	266	172	179	218	236
Lactate (mmol/l)	1.0	1.7	1.6	1.6	3.5	2.5	1.9	1.2	1.3	0.9
ALAT (U/l)	16	38	17	39	15	14	5	5	16	8
ASAT (U/l)	19	48	20	49	22	18	6	8	12	9
Bilirubin (μmol/l)	40	44	15	13	58	83	20	17	54	38

ALAT, alanine aminotransferase; APACHE II, Acute Physiologic and Chronic Health Evaluation; ASAT, aspartate aminotransferase; CI, cardiac index; HR, heart rate; MAP, mean arterial pressure; MOD, Multiple Organ Dysfunction; NE, norepinephrine; PaO₂/FiO₂, partial arterial oxygen tension/inspirator oxygen fraction.

ISSN: 1364-8535