Table 1 Physiological parameters during endotoxin infusion
Group | |||
|---|---|---|---|
Parameter Time (h) | Saline | Ceftazidime | Tobramycin |
Mean pulmonary arterial pressure (mmHg) | |||
0 | 16.5 ± 0.9 | 17.4 ± 0.9 | 18.0 ± 2.4 |
1 | 29.0 ± 2.7 | 29.4 ± 1.5 | 30.5 ± 3.3 |
2 | 34.8 ± 3.1 | 35.2 ± 2.4 | 37.5 ± 2.6 |
3 | 36.3 ± 3.6 | 39.8 ± 3.3 | 37.0 ± 2.9 |
4 | 32.5 ± 1.3 | 36.0 ± 3.2 | 32.5 ± 1.6 |
5 | 30.8 ± 0.6 | 36.0 ± 4.0 | 30.0 ± 2.1 |
6 | 29.3 ± 0.9 | 35.5 ± 3.8 | 28.3 ± 2.7 |
Mean arterial pressure (mmHg) | |||
0 | 87.5 ± 11.6 | 104.2 ± 5.6 | 100.5 ± 13.9 |
1 | 119.0 ± 6.4 | 120.4 ± 8.9 | 87.8 ± 8.8 |
2 | 113.3 ± 6.2 | 110.2 ± 10.5 | 101.3 ± 5.7 |
3 | 93.0 ± 8.1 | 98.0 ± 14.8 | 97.3 ± 6.3 |
4 | 92.0 ± 19.1 | 94.0 ± 18.4 | 101.3 ± 8.5 |
5 | 95.0 ± 22.1 | 115.8 ± 8.6 | 107.5 ± 7.8 |
6 | 104.3 ± 21.9 | 120.0 ± 10.0 | 108.5 ± 7.1 |
Cardiac index (l/min per m2) | |||
0 | 4.6 ± 0.2 | 4.2 ± 0.1 | 4.0 ± 0.3 |
1 | 4.4 ± 0.4 | 4.2 ± 0.5 | 3.5 ± 0.2 |
2 | 3.6 ± 0.3 | 3.0 ± 0.3 | 2.6 ± 0.2 |
3 | 2.3 ± 0.2 | 2.1 ± 0.3 | 1.9 ± 0.1 |
4 | 2.5 ± 0.4 | 2.2 ± 0.4 | 2.0 ± 0.1 |
5 | 3.2 ± 0.6 | 3.2 ± 0.4 | 2.8 ± 0.3 |
6 | 3.8 ± 0.7 | 3.7 ± 0.4 | 3.4 ± 0.5 |
Arterial oxygen tension (kPa) | |||
0 | 21.1 ± 0.5 | 22.3 ± 0.4 | 21.1 ± 1.2 |
1 | 20.1 ± 0.7 | 21.0 ± 1.6 | 17.8 ± 2.9 |
2 | 19.1 ± 0.7 | 18.7 ± 1.8 | 16.5 ± 3.2 |
3 | 17.3 ± 1.1 | 17.7 ± 2.1 | 14.8 ± 3.0 |
4 | 17.7 ± 0.5 | 17.1 ± 1.8 | 15.2 ± 2.5 |
5 | 18.0 ± 0.6 | 17.9 ± 1.5 | 17.1 ± 2.4 |
6 | 18.0 ± 0.5 | 17.8 ± 1.7 | 17.3 ± 2.4 |
Base excess (mmol/l) | |||
0 | 7.0 ± 1.1 | 5.6 ± 0.7 | 6.5 ± 0.5 |
1 | 3.0 ± 0.9 | 1.2 ± 1.0 | 1.0 ± 0.8 |
2 | 2.3 ± 0.9 | 1.4 ± 1.0 | 1.3 ± 0.5 |
3 | -0.8 ± 1.1 | -1.8 ± 2.3 | -1.0 ± 0.7 |
4 | -2.8 ± 2.2 | -5.0 ± 3.6 | -1.8 ± 0.5 |
5 | -1.0 ± 2.3 | -0.3 ± 0.8 | -0.8 ± 0.3 |
6 | 0.0 ± 1.7 | -0.5 ± 0.8 | -0.8 ± 0.3 |
Neutrophil granulocyte count (109/l) | |||
0 | 6.9 ± 2.0 | 6.3 ± 1.5 | 5.7 ± 1.5 |
1 | 1.4 ± 0.2 | 1.0 ± 0.2 | 0.9 ± 0.2 |
2 | 0.9 ± 0.2 | 1.5 ± 0.6 | 0.4 ± 0.2 |
3 | 1.8 ± 0.4 | 2.4 ± 0.6 | 1.5 ± 0.6 |
4 | 2.3 ± 0.4 | 2.4 ± 0.7 | 1.8 ± 0.4 |
5 | 3.4 ± 0.3 | 2.8 ± 0.3 | 3.1 ± 1.1 |
6 | 4.0 ± 0.2 | 2.9 ± 0.7 | 5.1 ± 1.9 |