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Table 1 Red blood cell storage lesion

From: Age of blood: does it make a difference?

Storage effects Consequences
Decreased 2, 3-diphosphoglycerate Increased oxygen affinity and decreased oxygen unloading by hemoglobin
ATP depletion Erythrocyte shape changes
  Increased osmotic fragility
  Decreased deformability
Microvesiculation and loss of lipid membrane Decreased erythrocyte viability
Lipid peroxidation Cellular injury and death
Bioactive substance generation: histamine, cytokines, lipids Febrile transfusion reactions
  Neutrophil priming/endothelial activation
  Cellular injury
  Transfusion-related acute lung injury
  Multiple organ failure (?)