Storage effects | Consequences |
---|---|
Decreased 2, 3-diphosphoglycerate | Increased oxygen affinity and decreased oxygen unloading by hemoglobin |
ATP depletion | Erythrocyte shape changes |
 | Increased osmotic fragility |
 | Decreased deformability |
Microvesiculation and loss of lipid membrane | Decreased erythrocyte viability |
Lipid peroxidation | Cellular injury and death |
Bioactive substance generation: histamine, cytokines, lipids | Febrile transfusion reactions |
 | Neutrophil priming/endothelial activation |
 | Cellular injury |
 | Transfusion-related acute lung injury |
 | Multiple organ failure (?) |