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Table 1 Patient demographic and clinical characteristics (safety population)

From: Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment

  

Degree of renal impairment

Characteristic

Normal/mild

Moderate/severe

Number of patients treated

10

30

Reason for ICU admittance

  

   Cardiac postsurgical

4 (40%)

7 (23%)

   General postsurgical

0

10 (33%)

   Medical

6 (60%)

13 (44%)

Respiratory

4 (40%)

8 (27%)

Sepsis

0

3 (10%)

Cardiovascular

1 (10%)

1 (3%)

Trauma

1 (10%)

0

Haematological

0

1 (3%)

Mean SAPS II (range)

41.0 (31–57)

53.2 (16–91)

Mean CLcr (ml/min) at screening (range)

62.9 (44–84)

13.7 (0–49)

Mean renal dysfunction score at screening (range)

2.3 (0–3)

4.3 (1–5)

Renal replacement therapy

0

14 (47%)

Mean baseline SAS score (range)

2.9 (2–4)

2.4 (2–4)

Mean baseline PI score (range)

1.2 (1–2)

1.1 (1–3)

Mean baseline RR (breaths/min; range)

15.6 (10–22)

14.7 (0–39)

Mean baseline MAP (mmHg; range)

79.0 (53–105)

78.3 (56–135)

Mean baseline HR (beats/min; range)

85.6 (61–126)

94.7 (62–128)

Mean age (years; range)

68.6 (54–78)

65.7 (31–81)

Sex

  

   Male

9 (90%)

22 (73%)

   Female

1 (10%)

8 (27%)

Mean height (cm; range)

173.2 (157–180)

167.5 (120–188)

Mean weight (kg; range)

79.6 (68–96)

75.6 (38.3–110)

  1. Renal function was assessed by estimating the patient's creatinine clearance (CLcr), as described under Methods. Normal renal function/mild renal impairment was defined as an estimated CLcr ≥ 50 ml/min. Moderate/severe renal impairment was defined as an estimated CLcr <50 ml/min. Logistic Organ Dysfunction Score [18]. HR, heart rate; ICU, intensive care unit; MAP, mean arterial pressure; PI, Pain Intensity (scale); RR, respiratory rate; SAPS, Simplified Acute Physiology Score [23]; SAS, Sedation–Agitation Scale.