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Table 4 Mean percentage of hours of optimal sedation (intent to treat population)

From: Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial [ISRCTN43755713]

  Remifentanil (n = 77)   Fentanyl (n = 75) P
Maintenance phase     
   Median duration (h; range) 13.7 (2.7–73.0)   14.2 (0.3–73.3) NT
   Mean (range) % of hours of optimal sedation 88.3 (0.0–100.0)   89.3 (32.5–100.0) NS*
   Ratio of between-patient variability (fentanyl versus remifentanil)   1.09   NS
Maintenance phase (excluding the patient in the remifentanil group who failed to achieve an SAS score of 4)     
   Mean (range) % of hours of optimal sedation 89.5 (45.2–100.0)   89.3 (32.5–100.0) NS*
   Ratio of between-patient variability (fentanyl versus remifentanil)   1.84   0.009
Extubation phase     
   Mean (range) % of hours of optimal sedation 87.7 (0.0–100.0)   95.5 (40.0–100.0) NT
Postextubation phase     
   Mean (range) % of hours of optimal sedation 92.3 (0.0–100.0)   95.7 (32.3–100.0) NT
Post-treatment period     
   Mean (range) % of hours of optimal sedation 92.6 (0.0–100.0)   91.6 (0.0–100.0) NT
  1. *Unpaired t-test on arcsine square root transformed data; F test. NS, not significant; NT, not tested; SAS, Sedation–Agitation Scale.