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Figure 5 | Critical Care

Figure 5

From: Bench-to-bedside review: Microvascular dysfunction in sepsis –hemodynamics, oxygen transport, and nitric oxide

Figure 5

Relationships between global hemodynamics, tissue oxygen tension (PO2), and skeletal muscle lactate and ATP. In a 6-hour rat model of sepsis (cecal ligation and perforation [CLP]), fluid resuscitation was found to prevent decreases in systemic oxygen delivery (DO2) and tissue PO2 in skeletal muscle (tPO2). This apparent rescue of the muscle microcirculation was belied by elevated lactate and reduced ATP. *P < 0.05, versus control. FR, albumin fluid resuscitation; MAP, mean arterial pressure. By permission from Circ Shock 1988, 26:311–20 [35].

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Critical Care

ISSN: 1364-8535