|  |  |  |  | Mortality (%) |  |  | |
---|---|---|---|---|---|---|---|---|
Ref. | Year | No. of patients | Type of patients | Protocol target | Protocol | Control | P | Comments |
[17] | 1992 | 51 | Septic shock | CI ≥ 6.0 | 72 | 50 | 0.14 |  |
[18] | 1993 | 67 | Medical and surgical | DO2 >600 | 34 | 34 | NS | 52 patients with sepsis |
[22] | 1994 | 100 | Medical and surgical | CI >4.5, DO2 >600, VO2 >170 | 54 | 34 | 0.04 | 72 patients with sepsis |
[21] | 1995 | 762 | Medical and surgical | Protocol group 1: CI >4.5 | 48.4 | 52.1 | 0.64 | No difference in mortality in the subgroup with sepsis |
 |  |  |  | Protocol group 2: SvO2 >70% | 48.6 |  |  |  |
[19] | 1995 | 89 | Surgical patients | DO2 >599 | NA | NA | NS | Majority with sepsis |
[23] | 1998 | 105 | Surgical patients (99 with sepsis) | DO2 >600 | 9 | 12 | 0.01 | Subgroup 50-75 years |
 |  |  |  |  | 12 | 11 | 0.99 | Subgroup >75 years |
[20] | 1999 | 63 | Severe sepsis or septic shock | DO2 >600 | 74 | 66 | 0.46 | Â |