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Table 1 Randomized controlled trials of high cardiac output in patients with sepsis

From: The International Sepsis Forum's frontiers in sepsis: high cardiac output should not be maintained in severe sepsis

     

Mortality (%)

  

Ref.

Year

No. of patients

Type of patients

Protocol target

Protocol

Control

P

Comments

[17]

1992

51

Septic shock

CI ≥ 6.0

72

50

0.14

 

[18]

1993

67

Medical and surgical

DO2 >600

34

34

NS

52 patients with sepsis

[22]

1994

100

Medical and surgical

CI >4.5, DO2 >600, VO2 >170

54

34

0.04

72 patients with sepsis

[21]

1995

762

Medical and surgical

Protocol group 1: CI >4.5

48.4

52.1

0.64

No difference in mortality in the subgroup with sepsis

    

Protocol group 2: SvO2 >70%

48.6

   

[19]

1995

89

Surgical patients

DO2 >599

NA

NA

NS

Majority with sepsis

[23]

1998

105

Surgical patients (99 with sepsis)

DO2 >600

9

12

0.01

Subgroup 50-75 years

     

12

11

0.99

Subgroup >75 years

[20]

1999

63

Severe sepsis or septic shock

DO2 >600

74

66

0.46

 
  1. CI, cardiac index; DO2, oxygen delivery; NA, not available; NS, not significant; VO2, oxygen consumption.