Table 1
Saline | Diclofenac | Enalapril | Losartan | D+E | D+L | |
|---|---|---|---|---|---|---|
Tail-cuff blood pressure | 167 ± 3.5 (n = 30) | 187 ± 2.9* (n = 27 | 149 ± 4.2* (n = 17 | 157 ± 3.3* (n = 18 | 148 ± 3.5* (n = 19 | 159 ± 4.4* (n = 21 |
Mean arterial blood 100% (n = 8) pressure | +3.8% (n = 8) | -13.9% (n = 11) | -21.8% (n = 6) | -20.3% (n = 6) | -33.8% (n = 6) | |
Rollers | 116.5 ± 9.3 (n = 8) | 25.4 ± 3.8*(n = 8) | 89.5 ± 7.8 (n = 9) | 65.2 ± 7.8* (n = 9) | 90.2 ± 9.4 (n = 9) | 58.6 ± 8.2* (n = 9) |
Adherent | 9.2 ± 0.5 (n = 9) | 3.8 ± 0.4* (n = 9) | 5.7 ± 0.3* (n = 9) | 6.2 ± 0.4* (n = 9) | 5.4 ± 0.4* (n = 9) | 6.5 ± 0.4* (n = 9) |
Migrated | 9.2 ± 0.6 (n = 9) | 4.7 ± 0.3* (n = 9) | 6.1 ± 0.4* (n = 9) | 6.6 ± 0.4* (n = 9) | 5.5 ± 0.4* (n = 9) | 6.4 ± 0.5* (n = 9) |
Circulating leukocytes | 7500 ± 594.1 (n = 5) | 7970 ± 717.3 (n = 5) | 8250 ± 1233 (n = 5) | 6660 ± 299 (n = 5) | 8280 ± 626 (n = 5) | 10262 ± 916 (n = 4) |
Venular diameter | 15.9 ± 0.3 (n = 28) | 15.9 ± 0.3 (n = 25) | 16.4 ± 0.4 (n = 23) | 16.1 ± 0.2 (n = 24) | 16.4 ± 0.3 (n = 25) | 15.9 ± 0.4 (n = 26) |
Venular wall shear rate | 281.6 ± 16.7 (n = 5) | 217.1 ± 35.9 (n = 8) | 209.3 ± 23.8 (n = 12) | 121.0 ± 9.0* (n = 5) | 200.3 ± 28.0 (n = 6) | 205.4 ± 17.1 (n = 6) |
LECAM | 7.8 ± 0.1 (n = 3) | 9.9 ± 1.1 (n = 6) | 9.1 ± 0.1 (n = 3) | 6.9 ± 0.1 (n = 3) | 6.7 ± 0.3 (n = 3) | 7.0 ± 0.1 (n = 3) |
CD11-CD18 | 12.0 ± 4.2 (n = 5) | 14.9 ± 0.6 (n = 4) | 23.7 ± 4.2 (n = 3) | 17.4 ± 5.1 (n = 4) | 17.9 ± 6.0 (n = 5) | 15.5 ± 1.8 (n = 6) |
ICAM-1 | 57.6 ± 3.4 (n = 8) | 38.6 ± 0.8* (n = 7) | 41.3 ± 4.4* (n = 7) | 35.4 ± 1.9* (n = 7) | 41.3 ± 1.6* (n = 7) | 45.2 ± 1.8* (n = 7) |
P-selectin | 51.6 ± 2.2 (n = 11) | 37.1 ± 1.4* (n = 9) | 43.0 ± 1.3 (n = 6) | 34.1 ± 1.2* (n = 10) | 44.3 ± 4.1 (n = 6) | 37.2 ± 1.5* (n = 8) |