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Table 1

From: Influence of losartan and enalapril on the diclofenac effect on leukocyte–endothelium interaction in spontaneously hypertensive rats (SHR)

  Saline Diclofenac Enalapril Losartan D+E D+L
Tail-cuff blood pressure 167 ± 3.5 (n = 30) 187 ± 2.9* (n = 27 149 ± 4.2* (n = 17 157 ± 3.3* (n = 18 148 ± 3.5* (n = 19 159 ± 4.4* (n = 21
Mean arterial blood 100% (n = 8) pressure   +3.8% (n = 8) -13.9% (n = 11) -21.8% (n = 6) -20.3% (n = 6) -33.8% (n = 6)
Rollers 116.5 ± 9.3 (n = 8) 25.4 ± 3.8*(n = 8) 89.5 ± 7.8 (n = 9) 65.2 ± 7.8* (n = 9) 90.2 ± 9.4 (n = 9) 58.6 ± 8.2* (n = 9)
Adherent 9.2 ± 0.5 (n = 9) 3.8 ± 0.4* (n = 9) 5.7 ± 0.3* (n = 9) 6.2 ± 0.4* (n = 9) 5.4 ± 0.4* (n = 9) 6.5 ± 0.4* (n = 9)
Migrated 9.2 ± 0.6 (n = 9) 4.7 ± 0.3* (n = 9) 6.1 ± 0.4* (n = 9) 6.6 ± 0.4* (n = 9) 5.5 ± 0.4* (n = 9) 6.4 ± 0.5* (n = 9)
Circulating leukocytes 7500 ± 594.1 (n = 5) 7970 ± 717.3 (n = 5) 8250 ± 1233 (n = 5) 6660 ± 299 (n = 5) 8280 ± 626 (n = 5) 10262 ± 916 (n = 4)
Venular diameter 15.9 ± 0.3 (n = 28) 15.9 ± 0.3 (n = 25) 16.4 ± 0.4 (n = 23) 16.1 ± 0.2 (n = 24) 16.4 ± 0.3 (n = 25) 15.9 ± 0.4 (n = 26)
Venular wall shear rate 281.6 ± 16.7 (n = 5) 217.1 ± 35.9 (n = 8) 209.3 ± 23.8 (n = 12) 121.0 ± 9.0* (n = 5) 200.3 ± 28.0 (n = 6) 205.4 ± 17.1 (n = 6)
LECAM 7.8 ± 0.1 (n = 3) 9.9 ± 1.1 (n = 6) 9.1 ± 0.1 (n = 3) 6.9 ± 0.1 (n = 3) 6.7 ± 0.3 (n = 3) 7.0 ± 0.1 (n = 3)
CD11-CD18 12.0 ± 4.2 (n = 5) 14.9 ± 0.6 (n = 4) 23.7 ± 4.2 (n = 3) 17.4 ± 5.1 (n = 4) 17.9 ± 6.0 (n = 5) 15.5 ± 1.8 (n = 6)
ICAM-1 57.6 ± 3.4 (n = 8) 38.6 ± 0.8* (n = 7) 41.3 ± 4.4* (n = 7) 35.4 ± 1.9* (n = 7) 41.3 ± 1.6* (n = 7) 45.2 ± 1.8* (n = 7)
P-selectin 51.6 ± 2.2 (n = 11) 37.1 ± 1.4* (n = 9) 43.0 ± 1.3 (n = 6) 34.1 ± 1.2* (n = 10) 44.3 ± 4.1 (n = 6) 37.2 ± 1.5* (n = 8)
  1. Data presented as mean ± SEM. ICAM-1, intracellular adhesion molecule-1. *P < 0.05 vs saline.