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Table 1

From: Is it possible to use levosimedan to treat cardiovascular dysfunction in septic patients?

  Baseline* 18 h of treatment# After 1 h EVO** After 3 h EVO## 12 h with EVO 24 h with LEVO## Without LEVO 2 h Without LEVO 12 h Without LEVO 24 h Without LEVO 48 h
CI 1.4 2.8 2.8 3.3 3.2 4.2 3.6 3.6 3.7 4.4
MAP 73 92 78 70 70 66 73 88 79 93
PAOP 22 21 16 21 14 20 20 22 21 22
SVO2 68 75 78 79 75 74 74 75 73 77
VO2 85 90 94 102 111 123 122 119 143 121
Lactate 7.43 5.21 2.55 1.77 1.55 1.77 1.55 1.55 1.54 1.91
  1. Hemodynamic support: * 0.6 μg/kg/min noradrenalin + 20 μg/kg/min dobutamine. # 30 μg/kg/min dobutamine + 5 l Ringer's solution + 500 ml hydroxyethylstarch (HES) (200/0.5). ** 20 μg/kg/min dobutamine + 0.1 μg/kg/min levosimedan (LEVO). ## 0.2 μg/kg/min LEVO + 500 ml HES (200/0.5).