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Table 8 Classification by platelet counts of intracranial hemorrhages during infusion period and cross-classification with presence of meningitis in all clinical trials

From: Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis

 

ICH during infusion period

Platelets (×103/mm3)1

Events2

Cumulative % of patients

Meningitis

≤ 20

3/5

20.0% (3/15)

1/3

>20 to ≤ 30

3/6

40.0% (6/15)

1/3

>30 to ≤ 50

2/11

53.3% (8/15)

0/2

>50 to ≤ 100

3/12

73.3% (11/15)

2/3

>100

4/19

100.0% (15/15)

2/4

Not available

1/26

  

Total

16/79

 

6/16

  1. A total of 2786 patients treated with drotrecogin alfa (activated) infusion were included in this analysis. 1Platelet counts were recorded within the preceding 24 hours of an intracerebral hemorrhage (ICH). 2Patients with an ICH/all patients with a serious bleeding event.
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Critical Care

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