Science review: Genetic variability in the systemic inflammatory response

Table 1 An enormous number of genes have been identified as having potentially important polymorphic sites

Sites of specific polymorphism	Gene
Antigen recognition pathways	CD14
	TLR-4
	TLR-2
	HSP-70-1
	HSP-70-2
	HSP-70-HOM
Proinflammatory cytokines	TNF-α + receptors
	IL-1α + IL-1β + receptors
	IL-6, IL-2, IL-3,
	IL-8 + receptors
	IFN-γ
	IL-12
	IL-18
	GM-CSF
	IFN-α
	LT-α
Anti-inflammatory cytokines	IL-10
	IL-1Ra
	IL-13
	TGF-β₁ and TGF-β₂
	IL-4
	CTLA-4

CTLA, cytotoxic T-lymphocyte-associated antigen; GM-CSF, granulocyte/macrophage colony-stimulating factor; HSP, heat shock protein; IFN, interferon; IL-1Ra, interleukin 1 receptor antagonist; LT, lymphotoxin; TGF, transforming growth factor; TLR, Toll-like receptor; TNF, tumor necrosis factor.

ISSN: 1364-8535