Skip to main content

Table 2 Common findings in 39 cases of nucleosidic reverse transcriptase inhibitor-induced lactic acidosis

From: Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors

Clinical feature

Percent of cases

Asthaenia

70

Muscular weakness

20

Anorexia

40

Loss of weight

20

Fever or hypothermia

50

Nausea and vomiting

87.5

Abdominal pain

82

Hepatomegaly

75

Tachypnea

83

Laboratory findings

 

   Hyperlactataemia and metabolic acidosis

100

   Hepatic cytolysis

79

   Hepatic cholestasis

73

   Low prothrombin rate

45

   Elevated lacticodehydrogenase

100

   Macrovacuolar or microvacuolar steatosis

100