Table 1
Drug(s) used | Year | Complication | Comments |
|---|---|---|---|
Mefloquine | 1993–1997 | Prolonged parasitemia | High incidence of drug resistance and side effects |
Mefloquine + others | 1993–1997 | Nausea, vomiting | High incidence of gastro side effects |
Mefloquine + others + Quinine and outcome | 1993–1997 | Vomiting, intolerance | Neither cost nor time effective, unpredictable response |
Quinine | 1993–1999 | Mainly GI in PO administration | Better results in all types except MOF/shock |
Artesunate | 2000–2002 | Virtually nil | Drastic reduction of parasite index |
Artemether | 2000–2002 |  |  |
Quinine + Artesunate | 1999–2002 | Virtually nil; noteworthy is no prolongation of QT interval | Best combination to date; reserved for P.I. > 4%, failure to reduce P.I. by 25% in 48 hours and shock |