Figure 3From: Bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?Sepsis and coagulation-fibrinolysis pathways. Exposure to inflammatory and/or septic stimuli rapidly leads to procoagulant behaviour. The profibrinolytic property of endothelial cells (ECs) is blunted, due to decreased release of tissue plasminogen activator. This occurs in a context of increased plasminogen activator inhibitor (PAI)-1 release with antifibrinolysis. LPS, lipopolysaccharide; M, activated monocyte; SMC, smooth muscle cell; TF, tissue factor; TM, thrombomodulin.Back to article page