Figure 2From: Bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?Coagulation and fibrinolysis pathways. Unperturbed endothelial cells (ECs) provide anticoagulant (tissue factor pathway inhibitor [TFPI], protein C [PC], protein S [PS], thrombomodulin [TM], heparan sulphate [HS]) and fibrinolytic (tissue plasminogen activator [tPA]) properties. ATIII, antithrombin III; FXa, coagulation factor Xa; M, activated monocyte; PAI, plasminogen activator inhibitor; SMC, smooth muscle cell; TF, tissue factor.Back to article page