Reducing mortality in sepsis: new directions

Table 3 Therapeutic interventions: standard therapy versus EGDT

Intervention	0–6 hours	7–72 hours	0–72 hours
Fluid therapy (l)	-2.49^a	+1.98^b	+0.085
Receiving vasopressors (%)	+2.9	+13.8^d	+14.5^c
Receiving inotropes (%)	-12.9^a	-6.1	-6.2
Receiving red blood cell transfusion (%)	-45.6^a	-21.7^a	-23.9^a
Mechanical ventilation instituted (%)	+0.8	+14.6^a	+15.0^c
Pulmonary artery catheter use (%)	+3.4	+10.6^e	+13.9^b

A negative or positive value indicates how the control group therapy compares with the treatment group. ^a P < 0.001, ^b P = 0.01, ^c P = 0.02, ^d P = 0.03, ^e P = 0.04. EGDT, early goal-directed therapy.

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